53 documents found, page 1 of 6
Necrotizing Fasciitis Caused by Photobacterium damselae: The First Case in Port...
Guimarães, D; Ribeiro, L; Vieira, L; Coelho, RNecrotizing fasciitis is a severe soft tissue infection with a high mortality rate and therefore requires emergent surgical treatment. Several microorganisms can cause this infection, Photobacterium damselae being one of them, with only eight cases previously published in the literature. We report the first ever case of necrotizing fasciitis, caused by this microorganism, in Portugal. In this case report the pa...
Generation of Two Paclitaxel-Resistant High-Grade Serous Carcinoma Cell Lines W...
Nunes, M; Silva, PMA; Coelho, R; Pinto, C; Resende, A; Bousbaa, H; Almeida, GM; Ricardo, SDebulking surgery followed by chemotherapy are the standard of care for high-grade serous carcinoma. After an initial good response to treatment, the majority of patients relapse with a chemoresistant profile, leading to a poor overall survival. Chemotherapy regimens used in high-grade serous carcinomas are based in a combination of classical chemotherapeutic drugs, namely, Carboplatin and Paclitaxel. The mecha...
Regulation of invasion and peritoneal dissemination of ovarian cancer by mesoth...
Coelho, R; Ricardo, S; Amaral, AL; Huang, YL; Nunes, M; Neves, JP; Mendes, N; López, MN; Bartosch, C; Ferreira, V; Portugal, R; Lopes, JM; Almeida, RPeritoneal dissemination is a particular form of metastasis typically observed in ovarian cancer and the major cause for poor patient’s outcome. Identification of the molecular players involved in ovarian cancer dissemination can offer an approach to develop treatment strategies to improve clinical prognosis. Here, we identified mesothelin (MSLN) as a crucial protein in the multistep process of peritoneal disse...
Impulsive and premeditated aggression in male offenders with antisocial persona...
Azevedo, JC; Vieira-Coelho, M; Castelo-Branco, M; Coelho, R; Figueiredo-Braga, MIntroduction Aggression is a clinical symptom of various psychiatric disorders that can be conceptualised as a physical act towards another person with the intent to cause harm. In antisocial personality disorder (ASPD), aggression is a frequent manifestation that differently compromise therapeutic and prognostic goals according to its impulsive or premeditated categorisation. ASPD is characterised by high leve...
Collagen-rich omentum is a premetastatic niche for integrin a2-mediated periton...
Huang, YL; Liang, CY; Ritz, D; Coelho, R; Septiadi, D; Estermann, M; Cumin, C; Rimmer, N; Schötzau, A; López, MN; Fedier, A; Konantz, M; Vlajnic, TThe extracellular matrix (ECM) plays critical roles in tumor progression and metastasis. However, the contribution of ECM proteins to early metastatic onset in the peritoneal cavity remains unexplored. Here, we suggest a new route of metastasis through the interaction of integrin alpha 2 (ITGA2) with collagens enriched in the tumor coinciding with poor outcome in patients with ovarian cancer. Using multiple gen...
Comparing the Continuous Geboes Score With the Robarts Histopathology Index: De...
Magro, F; Lopes, J; Borralho, P; Lopes, S; Coelho, R; Cotter, J; Oliveira, A, et al.Background and aims: The histological status of ulcerative colitis [UC] patients in clinical and endoscopic remission has gained space as an important prognostic marker and a key component of disease monitoring. Our main aims were to compare two histological indexes-the continuous Geboes score [GS] and the Robarts Histopathology index [RHI]-regarding their definitions of histological remission and response, and...
Low Golimumab Trough Levels at Week 6 Are Associated With Poor Clinical, Endosc...
Magro, F; Lopes, S; Silva, M; Coelho, R; Portela, F; Branquinho, D; Correia, L; Fernandes, S; Cravo, M; Caldeira, P; Sousa, H T; Patita, M; Lago, PBackground and aims: Golimumab has an established exposure-response relationship in patients with ulcerative colitis [UC]. However, the association of serum golimumab trough levels [TL] with objective markers of disease activity, such as endoscopic and histological activity scores and concentrations of biomarkers, remains less understood. This report describes the relationship of serum golimumab TL at the end o...
Soluble Human Suppression of Tumorigenicity 2 Is Associated with Endoscopic Act...
Magro, F; Lopes, S; Silva, M; Coelho, R; Portela, F; Branquinho, D; Correia, L; Fernandes, S; Cravo, M; Caldeira, P; Tavares de Sousa, H; Patita, MBackground: Suppressor of Tumorigenicity 2 (ST2) is an IL33 receptor detected in the mucosa and serum of ulcerative colitis (UC) patients. We evaluated soluble ST2 (sST2) as a surrogate biomarker of disease outcome and therapeutic response, in moderate-to-severe UC patients treated with golimumab. Methods: We conducted an open-label single-arm multicentre prospective study. At screening/baseline, week 6 (W6) an...
Impact of a brief psychological intervention on lifestyle, risk factors and dis...
Fernandes, AC; McIntyre, T; Coelho, R; Prata, J; Maciel, MJIntroduction:This study examined the efficacy of a brief inpatient psychoeducational intervention on knowledge about acute coronary syndromes (ACS), control of risk factors, and adaptive health habits and lifestyle. The intervention was intended to facilitate rehabilitation after ACS and its short- and medium-term impact was assessed. Methods: One hundred and twenty-one patients with ACS, admitted to a central ...
Peripheral biomarkers for first-episode psychosis-opportunities from the neuroi...
Trovão, N; Prata, J; Vondoellinger, O; Santos, SG; Barbosa, MA; Coelho, RObjective Schizophrenia is a disabling disorder of unknown aetiology, lacking definite diagnostic method and cure. A reliable biological marker of schizophrenia is highly demanded, for which traceable immune mediators in blood could be promising candidates. We aimed to gather the best findings of neuroinflammatory markers for first-episode psychosis (FEP). Methods We performed an extensive narrative review of o...