2 documents found, page 1 of 1
Microglia/Astrocytes-Glioblastoma Crosstalk: Crucial Molecular Mechanisms and M...
Matias, Diana; Balça-Silva, Joana; da Graça, Grazielle C.; Wanjiru, Caroline M.; Macharia, Lucy W.; Nascimento, Carla Pires; Roque, Natalia R.In recent years, the functions of glial cells, namely, astrocytes and microglia, have gained prominence in several diseases of the central nervous system, especially in glioblastoma (GB), the most malignant primary brain tumor that leads to poor clinical outcomes. Studies showed that microglial cells or astrocytes play a critical role in promoting GB growth. Based on the recent findings, the complex network of ...
The involvement of mast cells in the irinotecan-induced enteric neurons loss an...
Nogueira, Ludmila T.; Costa, Deiziane V. S.; Gomes, Antoniella Souza; Martins, Conceição S.; Silva, Angeline M. H. P.; Coelho-Aguiar, Juliana M.Background The irinotecan (CPT-11) causes intestinal mucositis and diarrhea that may be related to changes in the enteric nervous system (ENS). In inflammatory condition, mast cells release a variety of pro-inflammatory mediators that can interact with the ENS cells. It has not been explored whether CPT-11 is able to alter the enteric glial and neuronal cell, and the role of mast cells in this effect. Therefore...