Abstract Introduction: Frailty is an age-related condition related to the decline of physiologic capacity and the increased vulnerability to stressors. It is associated with increased mortality, hospitalizations, and healthcare costs. Dialysis patients, due to age and comorbidities, are especially vulnerable to frailty. The aim of this review was to assess the impact of frailty on outcomes of vascular access fo...
Abstract Introduction: The clinical management of secondary hyperparathyroidism (SHPT) in chronic kidney disease (CKD) stages G3‑G4 patients currently faces several challenges. Although the understanding of SHPT has increased exponentially in recent years, many aspects regarding its diagnosis and management in non‑dialysis G3‑G4 CKD remain elusive. Specifically, while it is known that SHPT is linked to vitamin ...
ABSTRACT Arteriovenous fistulas (AVFs) are the first-choice vascular access for most HD patients. Up to 60% of AVFs do not mature adequately, mostly due to stenosis. Surgical and endovascular techniques can rescue up to 80% of these AVFs from primary failure, allowing them to be safely and effectively used in HD, preserving venous capital, and avoiding placement of CVCs and associated complications. This articl...
Vascular access (VA) care is a critical part of the management of end-stage renal disease. Optimal care is necessary to avoid underdialysis and VA loss, leading to increased morbidity, mortality, and health-care-associated costs. The cornerstone of VA surveillance is flow volume (Qa) measurement. One of the most common ways to quantify Qa in clinical practice is by using duplex ultrasound (DUS), which is based ...
Background: Membranous nephropathy (MN) is among the most common causes of nephrotic syndrome in nondiabetic adults. The podocytic M-type phospholipase A2 receptor (PLA2R) has been identified as the major antigenic target of the immune response that underlies primary membranous nephropathy (PMN). In the last decade, anti-PLA2R antibodies have been seen as promising diagnostic biomarkers for PMN. Other potential...
The cohort of older age pre-dialysis patients is growing steadily. However, Fistula First may not always be the best strategy due to poorer arteriovenous fistula outcomes in this population. This retrospective cohort study included data from 157 predialysis patients who underwent fistula placement in our centre. Their mean age was 68.1±12.4 years. 64.3% were male and 53.5% were diabetic. The median nephrology...
The typical progression of diabetic nephropathy is from the normoalbuminuric stage to microalbuminuria (urinary albumin creatinine rate, UACR, 30-300 mg/g) to end in overt proteinuria. A growing body of recent evidence has shown an accelerated decrease in glomerular filtration rate predominately seen in normoalbuminuric patients with type 2 diabetes. This discovery raises the the possibility of there being two ...
A embolia séptica pulmonar (ESP) é frequentemente a apresentação clínica de variadas doenças de etiologia infecciosa, por vezes subdiagnosticadas na prática clínica. Esta entidade foi descrita há cerca de 30 anos, quase sempre associada a toxicodependentes com endocardite infecciosa da válvula tricúspide. Ao longo das últimas três décadas, a epidemiologia desta síndroma sofreu alterações relevantes. No entanto,...