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Gadoteric acid and gadolinium exposure – what is the impact on kidney gene expr...
Coimbra, Carla; Rocha, Susana; Viana, Sofia D.; Rebelo, Rute; Valente, Maria João; Catarino, Cristina; Belo, Luís; Bronze-da-Rocha, Elsa; Reis, FlávioBackground: The nephrotoxicity of gadolinium [Gd (III)] has been reported, raising concerns about the safety of gadolinium-based contrast agents (GBCA). Gd (III) exposure, in renal tubular cells (HK-2), causes apoptosis, and leads to upregulation of genes related to lipogenesis/lipolysis and to signaling pathways related to inflammation/hypoxia [1].Gadoteric acid (Gd-DOTA), a macrocyclic GBCA, appears to be one...
Date: 2025
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Origin: Scientific Letters