23 documents found, page 1 of 3
Common and rare genetic risk variants in age-related macular degeneration and g...
Farinha, Cláudia; Barreto, Patrícia; Coimbra, Rita; Cachulo, Maria da Luz; Melo, Joana Barbosa; Cunha-Vaz, José; Lechanteur, Yara; Hoyng, Carel B.Purpose: To determine the contribution of common and rare genetic variants in age-related macular degeneration (AMD) in a Portuguese population from the Coimbra Eye Study (CES), and the genetic risk score (GRS). Methods: Participants underwent ophthalmologic examination and imaging. A centralized reading centre performed AMD staging. Genetic sequencing was carried out with the EYE-RISK assay. Sixty-nine single ...
Interaction between genetics and the adherence to the Mediterranean diet: the r...
Barreto, Patrícia; Farinha, Cláudia; Coimbra, Rita; Cachulo, Maria da Luz; Melo, Joana Barbosa; Lechanteur, Yara; Hoyng, Carel B.; Cunha-Vaz, JoséBackground Age-related macular degeneration (AMD) is a multifactorial degenerative disease of the macula. Different factors, environmental, genetic and lifestyle, contribute to its onset and progression. However, how they interconnect to promote the disease, or its progression, is still unclear. With this work, we aim to assess the interaction of the genetic risk for AMD and the adherence to the Mediterranean d...
Association of Systemic Medication Use with Glaucoma and Intraocular Pressure: ...
Vergroesen, Joëlle E.; Schuster, Alexander K.; Stuart, Kelsey V.; Asefa, Nigus G.; Cougnard-Grégoire, Audrey; Delcourt, Cécile; Schweitzer, CédricPurpose: To investigate the association of commonly used systemic medications with glaucoma and intraocular pressure (IOP) in the European population. Design: Meta-analysis of 11 population-based cohort studies of the European Eye Epidemiology Consortium. Participants: The glaucoma analyses included 143 240 participants and the IOP analyses included 47 177 participants. Methods: We examined associations of 4 ca...
Genética e Dieta Mediterrânica: Qual o Risco para a Degenerescência Macular da ...
Barreto, Patrícia; Farinha, Cláudia; Coimbra, Rita; Cachulo, Maria Luz; Barbosa Melo , Joana; Lechanteur , Yara; B. Hoyng , Carel; Cunha-Vaz, JoséINTRODUÇÃO: A degenerescência macular da idade (DMI) é uma doença degenerativa da mácula, responsável por perda de visão grave. Factores genéticos e ambientais podem contribuir para a doença. Alguns estudos já sugeriram que a dieta mediterrância pode ser protectora da do- ença, mas o estudo da interacção entre a dieta e a genética é limitado. O nosso objetivo foi avaliar o efeito da adesão à di...
Myocardial RNA sequencing reveals new potential therapeutic targets in heart fa...
Inácio, José M.; Cristo, Fernando; Pinheiro, Miguel; Vasques-Nóvoa, Francisco; Saraiva, Francisca; Nunes, Mafalda M.; Rosas, Graça; Reis, AndreiaHeart failure with preserved ejection fraction (HFpEF) represents a global health challenge, with limited therapies proven to enhance patient outcomes. This makes the elucidation of disease mechanisms and the identification of novel potential therapeutic targets a priority. Here, we performed RNA sequencing on ventricular myocardial biopsies from patients with HFpEF, prospecting to discover distinctive transcri...
Association of systemic medication use with glaucoma and intraocular pressure: ...
Vergroesen, Joëlle E.; Schuster, Alexander K.; Stuart, Kelsey V.; Asefa, Nigus G.; Cougnard-Grégoire, Audrey; Delcourt, Cécile; Schweitzer, CédricPurpose: To investigate the association of commonly used systemic medications with glaucoma and intraocular pressure (IOP) in the European population. Design: Meta-analysis of eleven population-based cohort studies of the European Eye Epidemiology (E3) consortium. Participants: A total of 143240 participants were included in the glaucoma analyses and 47177 participants in the IOP analyses. Methods: We examined ...
Genetic Associations with Age-related Macular Degeneration and Genetic Risk Sco...
Farinha, Claudia; Barreto, Patrícia; Coimbra, Rita; Cachulo, Maria Luz; Melo, Joana Barbosa; Hoyng, Carel B.; Cunha-Vaz , José; Murta, JoaquimIntroduction: To date several genetic variants are known to play an important role in age-related macular degeneration(AMD). Variations in the genetic pool of different populations impact the disease prevalence, incidence and risk of progression. This report aims to determine the genetic contribution in the development of AMD in a Portuguese population from the Coimbra Eye Study (CES,NCT01298674,NCT02748824), a...
Characterization of One-Year Progression of Risk Phenotypes of Diabetic Retinop...
Ribeiro, Luísa; Marques, Inês P.; Coimbra, Rita; Santos, Torcato; Madeira, Maria H.; Santos, Ana Rita; Barreto, Patrícia Susana Correia LopesIntroduction: We characterized the progression of different diabetic retinopathy (DR) phenotypes in type 2 diabetes (T2D). Methods: A prospective longitudinal cohort study (CORDIS, NCT03696810) was conducted with three visits (baseline, 6 months, and 1 year). Demographic and systemic data included age, sex, diabetes duration, lipid profile, and hemoglobin A1c (HbA1c). Ophthalmological examinations included best...
Characterization of one-year progression of risk phenotypes of diabetic retinop...
Ribeiro, Luísa; Marques, Inês P.; Coimbra, Rita; Santos, Torcato; Madeira, Maria H.; Santos, Ana Rita; Barreto, Patrícia; Lobo, ConceiçãoWe characterized the progression of different diabetic retinopathy (DR) phenotypes in type 2 diabetes (T2D). A prospective longitudinal cohort study (CORDIS, NCT03696810) was conducted with three visits (baseline, 6 months, and 1 year). Demographic and systemic data included age, sex, diabetes duration, lipid profile, and hemoglobin A1c (HbA1c). Ophthalmological examinations included best-corrected visual acuit...
A conversion model for OCTA vessel density metrics in diabetic eyes: AngioVue v...
Santos, Ana Rita; Santos, Torcato; Coimbra, Rita; Pais, Inês; Marques, Inês P.; Cunha-Vaz, JoséG.To understand measurements variability between 2 different OCTA devices and to develop a conversion model that translate vascular metrics into a standardized and comparable value in patients with different stages of DR.