6 documents found, page 1 of 1
Synthesis, Antitubercular and Leishmanicidal Evaluation of Resveratrol Analogues
Coimbra,Elaine S.; Santos,Juliana A.; Lima,Larissa L.; Machado,Patrícia A.; Campos,Débora L.; Pavan,Fernando R.; Silva,Adilson D.In this paper we continue our efforts in the search for new Schiff bases as resveratrol analogues as promising antitubercular and antileishmanial agents. Compounds were evaluated in vitro against Mycobacterium tuberculosis and Leishmania species. Compounds showed varying activity against promastigotes of all Leishmania species tested (concentration leading to reduction of 50% of parasite growth-IC50 values rang...
Antileishmanial activity of some Brazilian plants, with particular reference to...
Antinarelli,Luciana M.R.; Pinto,Nícolas C.; Scio,Elita; Coimbra,Elaine S.Leishmaniasis is a complex of diseases caused by Leishmania protozoa which treatment is restricted to a limited number of drugs that exhibit high toxicity, collateral effects and are often costly. There are a variety of tropical plants distributed in Brazil, and for many poor people the therapy for several diseases is based mainly on the use of traditional herbal remedies. In this work, the cytotoxic activity o...
Essential oil of Mitracarpus frigidus as a potent source of bioactive compounds
Fabri,Rodrigo L.; Coimbra,Elaine S.; Almeida,Ana C.; Siqueira,Ezequias P.; Alves,Tânia M.A.; Zani,Carlos L.; Scio,ElitaIn our previous work (Fabri et al. 2009), we showed that different extracts of Mitracarpus frigidus had significant antibacterial, antifungal and leishmanicidal activities. In order to increase our knowledge about this species, this work assesses the chemical composition and the in vitro biological activity of its essential oil. Thus, the essential oil obtained by hydrodistillation of the aerial parts of M. fri...
Antitumor, antibiotic and antileishmanial properties of the Pyranonaphthoquinon...
Fabri,Rodrigo L.; Grazul,Richard M.; Carvalho,Lidiane O. de; Coimbra,Elaine S.; Cardoso,Gabriele M.M.; Souza-Fagundes,Elaine M. de; Silva,Adilson D. daThe bioactivity guided fractionation of the dichloromethane extract of Mitracarpus frigidus afforded the pyranonaphthoquinone psychorubrin. This compound, hitherto unknown in the genus Mitracarpus, had its biological activity evaluated against one panel of bacteria and two fungi, three tumor cell lines (HL60, Jurkat and MCF-7) and four Leishmania species. Its identity was confirmed unambiguously by ¹H, 13C, ¹H-...
Essential oil from leaves of Lantana camara: a potential source of medicine aga...
Machado,Rachel R. P.; Valente Júnior,Wilson; Lesche,Bernhard; Coimbra,Elaine S.; Souza,Nicolli B. de; Abramo,Clarice; Soares,Geraldo Luiz G.Leishmaniasis is an infection of viscera or tegument caused by protozoa Leishmania sp. The extensive period required for the treatment, which involves the use of toxic medicines, leads patients to drop treatment increasing the development of resistant forms of Leishmania sp. Lantana camara L., Verbenaceae, is a tropical plant native from America. Folk uses have been described for treatment of tumors, tetanus, r...
Atividades antimicrobiana e leishmanicida das sementes de Pterodon emarginatus ...
Dutra,Rafael C.; Braga,Fernanda G.; Coimbra,Elaine S.; Silva,Adilson D.; Barbosa,Nádia R.O presente trabalho investigou as atividades antimicrobiana e leishmanicida das sementes de Pterodon emarginatus Vogel. O potencial antimicrobiano do óleo essencial (OE) obtido das sementes foi avaliado através dos testes de difusão em ágar (10, 25 e 50 mg) e determinação da concentração inibitória mínima e utilizou os microorganismos-padrão: Staphylococcus aureus ATCC 25923, Streptococcus mutans ATCC 25175, Ps...