12 documents found, page 1 of 2
Assessing plume impacts caused by polymetallic nodule mining vehicles
Weaver, P.P.E.; Aguzzi, J.; Boschen-Rose, R.E.; Colaço, A.; de Stigter, H.; Gollner, S.; Haeckel, M.; Hauton, C.; Helmons, R.; Jones, D.O.B.; Lily, H.Deep-sea mining may be just a few years away and yet society is struggling to assess the positive aspects, such as increasing the supply of metals for battery production to fuel the green revolution, versus the potentially large environmental impacts. Mining of polymetallic (manganese) nodules from the deep ocean is likely to be the first mineral resource targeted and will involve direct impacts to hundreds of ...
Application of scientific criteria for identifying hydrothermal ecosystems in n...
Gollner, S.; Colaço, A.; Gebruk, A.; Halpin, P. N.; Higgs, N.; Menini, E.; Mestre, Nélia; Qian, P. Y.; Sarrazin, J.; Szafranski, K.; Van Dover, C. L.Deep-sea hydrothermal vent fields are globally rare (abundant in numbers, but extremely small in area) and are rich in extraordinary life based on chemosynthesis rather than photosynthesis. Vent fields are also sources of polymetallic sulfides rich in copper and other metals. Mineral resources of the international seabed beyond national jurisdictions (referred to as the “Area”) are administered by the Internati...
Research is needed to inform environmental management of hydrothermally inactiv...
Van Dover, C.L.; Colaço, A.; Collins, P.C.; Croot, P.; Metaxas, A.; Murton, B.J.; Swaddling, A.; Boschen-Rose, R.E.; Carlsson, J.; Cuyvers, L.Polymetallic sulfide (PMS) deposits produced at hydrothermal vents in the deep sea are of potential interest to miners. Hydrothermally active sulfide ecosystems are valued for the extraordinary chemosynthetic communities that they support. Many countries, including Canada, Portugal, and the United States, protect vent ecosystems in their Exclusive Economic Zones. When hydrothermal activity ceases temporarily (d...
Ecossistemas do Mar Profundo
Colaço, A.; Carreiro e Silva, M.; Giacomello, E. ., Gomes-Pereira, J. N., Menezes, G., Barros; Gordo, L; Vieira, A.; Adão, H.; Gomes-Pereira, J. N.Terra é um planeta azul, em que 70% da superfície está ocupada por mar. Mais de 90% desse enorme volume está a profundidades superiores a 200 metros, onde a luz escasseia e a vida toma contornos diferentes dos que se observam nas zonas onde a energia solar penetra. O fundo do mar, na sua escuridão, é a última grande fronteira marinha a ser explorada. Denominado “mar profundo”, esse gigantesco ambiente, cujo pot...
Trihalomethanes in liver pathology: Mitochondrial dysfunction and oxidative str...
Faustino-Rocha, A.I.; Rodrigues, D.; da Costa, R.G.; Diniz, C.; Aragão, S.; Talhada, D.; Botelho, M.; Colaço, A.; Pires, M.J.; Peixoto, F.Trihalomethanes (THMs) are disinfection byproducts found in chlorinated water, and are associated with several different kinds of cancer in human populations and experimental animal models. Metabolism of THMs proceeds through enzymes such as GSTT1 and CYP2E1 and gives rise to reactive intermediates, which form the basis for their toxic activities. The aim of this study was to assess the mitochondrial dysfunctio...
Effects of trihalomethanes on liver: a mouse model
Faustino-Rocha, A.I.; Rodrigues, D.; Vala, Helena; Pires, M.J.; Colaço, A.; Oliveira, P.A.Introduction and objectives: Trihalomethanes (THMs) are disinfection byproducts found in chlorinated water. They are associated with cancer of various organs in human populations and experimental animal models. The aim of this study was to evaluate by histopathology the hepatic changes induced by THMs administered at low levels in a mouse model. Materials and methods: All procedures were made in accordance to t...
E-Cadherin and β-Catenin Expression during Urothelial Carcinogenesis Induced by...
Vasconcelos-Nóbrega, C.; Costa, C.; Vala, Helena; Colaço, A.; Santos, L.; Lopes, C.; Oliveira, PABACKGROUND: E-cadherin and β-catenin are adhesion molecules that promote integrity and stability of the urothelium. A decrease in theirexpression is associated with more aggressive tumour phenotypes with the ability to invade and metastasize. MATERIAL AND METHODS: 45 ICR male mice were used, of which 25 received N-butyl-N-(4-hydroxybutyl)nitrosamine (0.05%) in drinking water for a period of 12 weeks. Immunohist...
Sex differences in bladder cancer chemoprevention by green tea
Videira-Henriques, A.; Ferreira, S.; Almeida, L.; Arantes-Rodrigues, R.; Vasconcelos-Nóbrega, C.; Vala, Helena; Colaço, A.; Oliveira, P. A.Background: In bladder cancer prevention studies, is important to investigate how both sexes respond to different agents. The purpose of this experiment was to evaluate the protective effect of green tea consumption in bladder cancer induced by N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in Mus musculus of both sexes. Methods: 21 male and 20 female mice were randomly assigned into three groups (I-Green tea+BBN,...
Meloxicam inhibits the progression of mice urothelial lesions chemically induced
R Arantes-Rodrigues, A Colaço, PA Oliveira; Videira-Henriques, A.; Ribeiro, C.; Vasconcelos-Nóbrega, C.; Pinto-Leite, R.; Vala, Helena; Lopes, C.Meloxicam, an anti-inflammatory drug, is a cyclooxygenase-2 inhibitor that has been used in cancer research. The goal of this work was to evaluate the effects of meloxicam on mouse urothelial lesions chemically induced. During 12 weeks, ICR male mice received N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in drinking water, after meloxicam was administered by intraperitoneal route (20 mg/kg), 5 days a week, during...
Experimental study of the anticancer effect of gemcitabine combined with siroli...
Vasconcelos-Nóbrega, C.; Colaço, A.; Santos, L.; Vala, Helena; Palomino, LF; Lopes, C.; Oliveira, PABACKGROUND: The purpose of this study was to determine the efficacy of a combination of gemcitabine and sirolimus in a mouse model of invasive bladder cancer. MATERIALS AND METHODS: Gemcitabine (50 mg/kg) and sirolimus (1.5 mg/kg) were administered to animals previously exposed to N-butyl-N-4(hydroxybutyl)nitrosamine in drinking water. Tumour development was determined by histopathological evaluation. RESULTS: ...