12 documents found, page 1 of 2

Long-term treatment with chaethomellic acid A reduces glomerulosclerosis and ar...

The high prevalence of end-stage renal disease emphasizes the failure to provide therapies to effectively prevent and/or reverse renal fibrosis. Therefore, the aim of this study was to evaluate the effect of long-term treatment with chaethomellic acid A (CAA), which selectively blocks Ha-Ras farnesylation, on renal mass reduction-induced renal fibrosis. Male Wistar rats were sham-operated (SO) or subjected to 5...

Long-term treatment with chaethomellic acid A reduces glomerulosclerosis and ar...

The high prevalence of end-stage renal disease emphasizes the failure to provide therapies to effectively prevent and/or reverse renal fibrosis. Therefore, the aim of this study was to evaluate the effect of long-term treatment with chaethomellic acid A (CAA), which selectively blocks Ha-Ras farnesylation, on renal mass reduction-induced renal fibrosis. Male Wistar rats were sham-operated (SO) or subjected to 5...

Biomonitoring of heavy metals (Cd, Hg, and Pb) and metalloid (As) with the Port...

Effect of chaethomellic acid on renal function in rat model of chronic renal fa...

To study the effect of chronic treatment with chaethomellic acid (CA), a highly specific inhibitor of ras farnesyl-protein transferase, on the renal function of rats with renal failure induced by renal mass reduction. Male Wistar rats were subjected to 5/6 nephrectomy (RMR) or sham-operated (SO). One week after surgery, rats have been placed in four experimental groups: RMR: rats without treat- ment (n=13); RMR...

Effect of chaethomellic acid on renal function in a rat model of chronic renal ...

To study the effect of chronic treatment with chaethomellic acid (CA), a highly specific inhibitor of ras farnesyl-protein transferase, on the renal function of rats with renal failure induced by renal mass reduction. Male Wistar rats were subjected to 5/6 nephrectomy (RMR) or sham-operated (SO). One week after surgery, rats have been placed in four experimental groups: RMR: rats without treat- ment (n=13); RMR...

Effects of nebivolol on liver fibrosis induced by bile duct ligation in wistar ...

Everolimus combined with cisplatin has a potential role in treatment of urothel...

The effects of repeated oral gavage on the health of male CD-1 mice

In vivo and in vitro effects of RAD001 on bladder cancer

Objective: To evaluate the influence of Everolimus (RAD001) on chemically induced urothelial lesions in mice and its influence on in vitro human bladder cancer cell lines. Methods: ICR male mice were given N-butyl-N-(4-hydroxybutyl) nitrosamine in drinking water for a period of 12 weeks. Subsequently, RAD001 was administered via oral gavage, for 6 weeks. At the end of the experiment, all the animals were sacrif...

Effect of olive leaves on lipid and liver biochemical parameters in New Zealand...

In this experimental work was studied the effect of Olive leaf addition to diets of New Zealand white X California rabbits (Oryctolagus cuniculus cuniculus) on lipid and liver biochemical parameters.