12 documents found, page 1 of 2
The influence of Castanea sativa Mill. flower extract on hormonally and chemica...
Nascimento-Gonçalves, Elisabete; Seixas, Fernanda; Silva, Marcelo Aparecido de Souza; Fardilha, Margarida; Ferreira, Rita; Neuparth, Maria JoãoProstate cancer (PCa) is one of the most common cancers in men, with a huge impact on their health. The use of Castanea sativa Mill. flowers (CFs) in beverages has been reported, through ancestral claims, as having health benefits. In vitro research has evidenced the properties of CFs, such as antitumor and antioxidant activities. This study aimed to evaluate the effects of CF extract in an animal model of PCa....
The influence of Castanea sativa Mill. flower extract on hormonally and chemica...
Nascimento-Gonçalves, E.; Seixas, F.; Silva, M.; Fardilha, M.; Ferreira, R.; Neuparth, M. J.; Faustino-Rocha, A. I.; Colaço, B.; Venâncio, C.Prostate cancer (PCa) is one of the most common cancers in men, with a huge impact on their health. The use of Castanea sativa Mill. flowers (CFs) in beverages has been reported, through ancestral claims, as having health benefits. In vitro research has evidenced the properties of CFs, such as antitumor and antioxidant activities. This study aimed to evaluate the effects of CF extract in an animal model of PCa....
Encapsulated bacteriophages in alginate-nanohydroxyapatite hydrogel as a novel ...
Barros, J.; Melo, Luís Daniel Rodrigues; Silva, R. A.; Ferraz, M. P.; Azeredo, Joana; Pinheiro, V.; Colaço, B.; Fernandes, M. H.; Gomes, P. S.An innovative delivery system based on bacteriophages-loaded alginate-nanohydroxyapatite hydrogel was developed as a multifunctional approach for local tissue regeneration and infection prevention and control. Bacteriophages were efficiently encapsulated, without jeopardizing phage viability and functionality, nor affecting hydrogel morphology and chemical composition. Bacteriophage delivery occurred by swellin...
Laurus nobilis (laurel) aqueous leaf extract's toxicological and anti-tumor act...
Medeiros-Fonseca, Beatriz; Mestre, V.F.; Colaço, B.; Pires, Maria João; Martins, Tânia; Costa, Rui Miguel Gil; Neuparth, Maria João; Medeiros, RuiCancers induced by human papillomavirus (HPV) infection remain a significant public health threat, fueling the study of new therapies. Laurel (Laurus nobilis) compounds and extracts recently showed in vitro activity against HPV-transformed cell lines. This work aims to evaluate the in vivo efficacy and hepatic toxicity of a laurel extract in a transgenic mouse model of HPV16-induced cancer. The extract was admi...
New therapeutic approaches on chronic kidney disease
Nogueira, A.; Vala, Helena; Nóbrega, Carmen; Pires, C. A.; Colaço, B.; Oliveira, P. A.; Pires, M. J.Introduction: chronic kidney disease is a serious public health problem that affects millions of patients worldwide. So, the main research goals in the CKD patients are the research of new therapeutic approaches capable of slowing down the progression to end-stage renal disease. Objective: the aim of this work, was to evaluate the effects of chronic administration of chaetomellic acid A (CAA), which selectively...
Effects of exercise training on breast cancer metastasis in a rat model
Alvarado, A.; Gil da Costa, R. M.; Faustino-Rocha, A.I.; Ferreira, R.; Lopes, C.; Oliveira, P. A.; Colaço, B.
Diels–Alder functionalized carbon nanotubes for bone tissue engineering : in vi...
Mata, Diogo; Amaral, M.; Fernandes, A. J. S.; Colaço, B.; Gama, A.; Paiva, M. C.; Gomes, P. S.; Silva, R. F.; Fernandes, M. H.The risk-benefit balance for carbon nanotubes (CNTs) dictates their clinical fate. To take a step forward at this crossroad it is compulsory to modulate the CNT in vivo biocompatibility and biodegradability via e.g. chemical functionalization. CNT membranes were functionalised combining a Diels–Alder cycloaddition reaction to generate cyclohexene (–C6H10) followed by a mild oxidisation to yield carboxylic acid ...
Effect of chronic therapy with chaethomellic acid A on renal fibrosis in 5/6 ne...
Nogueira, A.; Vala, Helena; Nóbrega, C.; Pires, C. A.; Colaço, B.; Oliveira, P. A.; Pires, M. J.Objective: The high prevalence of chronic kidney disease underscores the failure to provide therapies to effectively halt, prevent, and/or reverse renal fibrosis. Thus, the aim of this study was to evaluate the effect of chronic treatment with chaethomellic acid A (CA) on renal fibrosis associated to 5/6 nephrectomy. Methods: Male Wistar rats were subjected to 5/6 nephrectomy (RMR) or sham-operated (SO). One we...
Effects of intense pulsed light on skin carcinogenesis
Faustino-Rocha, AI; Gama, A.; Rodrigues, D.; Colaço, B.; Vala, Helena; Pires, MJ; Oliveira, PAObjective: Intense pulsed light (IPL) is a non-laser high intensity light that has been used to the treatment of several skin conditions. This work intended to evaluate the effects of IPL on a mouse model of two-stage skin carcinogenesis. Methods: Procedures were made in accordance with the Directive 2010/63/EU. Sixteen DBA/2JRccHsd mice were divided into two groups: IPL-exposed and non-exposed. The carcinogen ...
Biomechanical and physicochemical characterization of the rat’s osteoporotic bone
Santos, C.; Carmezim, M. J.; Valido, A. J.; Colaço, B.; Fernandes, M. H.; Gomes, P.Osteoporosis is a clinical condition characterized by an increased risk of bone fracture. Structural fragility seems to result from a reduction in bone mass due to a decreased mineral content and impaired/altered protein synthesis. Despite the established knowledge on osteoporosis, little is known on how these compositional changes may affect the bone microarchitecture throughout different bones, and how these ...