6 documents found, page 1 of 1
Lrp1b: A giant lost in cancer translation
Príncipe, C; Sousa, IJD; Prazeres, H; Soares, P; Lima, RTLow-density lipoprotein receptor-related protein 1B (LRP1B) is a giant member of the LDLR protein family, which includes several structurally homologous cell surface receptors with a wide range of biological functions from cargo transport to cell signaling. LRP1B is among the most altered genes in human cancer overall. Found frequently inactivated by several genetic and epigenetic mechanisms, it has mostly been...
Clinical validation of a urine test (uromonitor-V2(®)) for the surveillance of ...
Sieverink, CA; Batista, R; Prazeres, H; Vinagre, J; Sampaio, C; Leão, RR; Máximo, V; Alfred Witjes, J; Soares, PThe costly and burdensome nature of the current follow-up methods in non-muscle-invasive bladder cancer (NMIBC) drives the development of new methods that may alternate with regular cystoscopy and urine cytology. The Uromonitor-V2® is a new urine-based assay in the detection of hotspot mutations in three genes (TERT, FGFR3, and KRAS) for evaluation of disease recurrence. The aim of this study was to investigate...
Biomarkers for bladder cancer diagnosis and surveillance: A comprehensive review
Batista, R; Vinagre, N; Meireles, S; Vinagre, J; Prazeres, H; Leão, R; Máximo, V; Soares, PBladder cancer (BC) ranks as the sixth most prevalent cancer in the world, with a steady rise in its incidence and prevalence, and is accompanied by a high morbidity and mortality. BC is a complex disease with several molecular and pathological pathways, thus reflecting different behaviors depending on the clinical staging of the tumor and molecular type. Diagnosis and monitoring of BC is mainly performed by in...
Predictive biomarkers and patient outcome in platinum-resistant (PLD-treated) o...
Sousa, IJD; Marques, DS; Príncipe, C; Portugal, RV; Canberk, S; Prazeres, H; Lopes, JM; Gimba, ERP; Lima, RT; Soares, PIdentification of predictive biomarkers for ovarian cancer (OC) treatment, particularly in the platinum-resistant/refractory setting, is highly relevant for clinical management. E-cadherin, vimentin, and osteopontin (OPN) are proteins associated with tumor microenvironment (TME) remodelling that play key roles in cancer. This study aimed to evaluate the association between the staining patterns of these protein...
Validation of a Novel, Sensitive, and Specific Urine-Based Test for Recurrence ...
Batista, R; Vinagre, J; Prazeres, H; Sampaio, C; Peralta, P; Conceição, P; Sismeiro, A; Leão, R; Gomes, A; Furriel, F; Oliveira, C; Torres, JNBladder cancer (BC), the most frequent malignancy of the urinary system, is ranked the sixth most prevalent cancer worldwide. Of all newly diagnosed patients with BC, 70–75% will present disease confined to the mucosa or submucosa, the non-muscle-invasive BC (NMIBC) subtype. Of those, approximately 70% will recur after transurethral resection (TUR). Due to high rate of recurrence, patients are submitted to an i...
Frequency of TERT promoter mutations in human cancers
Vinagre, J; Almeida, A; Pópulo, H; Batista, R; Lyra, J; Pinto, V; Coelho, R; Celestino, R; Prazeres, H; Lima, L; Melo, M; Rocha, AG; Preto, A; Castro, PReactivation of telomerase has been implicated in human tumorigenesis, but the underlying mechanisms remain poorly understood. Here we report the presence of recurrent somatic mutations in the TERT promoter in cancers of the central nervous system (43%), bladder (59%), thyroid (follicular cell-derived, 10%) and skin (melanoma, 29%). In thyroid cancers, the presence of TERT promoter mutations (when occurring tog...