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Genetic Variability in CLU and Its Association with Alzheimer's Disease

Guerreiro, Rita J.; Beck, John; Gibbs, J. Raphael; Santana, Isabel; Rossor, Martin N.; Schott, Jonathan M.; Nalls, Michael A.; Ribeiro, Helena

Recently, two large genome wide association studies in Alzheimer disease (AD) have identified variants in three different genes (CLU, PICALM and CR1) as being associated with the risk of developing AD. The strongest association was reported for an intronic single nucleotide polymorphism (SNP) in CLU. To further characterize this association we have sequenced the coding region of this gene in a total of 495 AD c...

Date: 2010   |   Origin: Estudo Geral - Universidade de Coimbra
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Ubiquitin associated protein 1 is a risk factor for frontotemporal lobar degene...

Rollinson, Sara; Rizzu, Patrizia; Sikkink, Stephen; Baker, Matthew; Halliwell, Nicola; Snowden, Julie; Traynor, Bryan J.; Ruano, Dina; Cairns, Nigel

http://www.sciencedirect.com/science/article/B6T09-4VKMW0R-1/2/c38ac7e3dcb87f1e42d35a151a3f69b2

Date: 2009   |   Origin: Estudo Geral - Universidade de Coimbra
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