16 documents found, page 1 of 2

Estradiol replacement abolishes cardiovascular and intracranial changes induced...

The effects of β-estradiol (E2) on cardiovascular and intracranial responses, the renin-angiotensin-aldosterone system (RAAS) activity, and central nervous system inflammatory markers were investigated in an obesity-associated menopause model. Ovariectomized (OVX) or sham female adult Holtzman and Wistar rats were fed a high-fat diet (HFD; 46% and 60% fat from lipids) or standard diet (SD) (n = 5–6 animals/grou...

OptoBrain: A Wireless Sensory Interface for Optogenetics

Optogenetics leverages light to control neural circuits, but traditional systems are often bulky and tethered, limiting their use. This work introduces OptoBrain, a novel, portable wireless system for optogenetics designed to overcome these challenges. The system integrates modules for multichannel data acquisition, smart neurostimulation, and continuous processing, with a focus on low-power and low-voltage ope...

A microdevice in a submicron CMOS for closed-loop deep-brain stimulation (CLDBS)

Deep-brain stimulation (DBS) is a highly effective and safe medical treatment that improves the lives of patients with a wide range of neurological and psychiatric diseases. It has been established as a first-line tool in the treatment of these conditions for the past two decades. Closed-loop deep-brain stimulation (CLDBS) advances this tool further by automatically adjusting the stimulation parameters in real ...

Wireless device with energy management for mlosed-loop deep brain stimulation (...

Deep brain stimulation (DBS) is an effective and safe medical treatment that improves the lives of patients with a wide range of neurological and psychiatric diseases, and has been consolidated as a first-line tool in the last two decades. Closed-loop deep brain stimulation (CLDBS) pushes this tool further by automatically adjusting the stimulation parameters to the brain response in real time. The main contrib...

Editorial: integrative physiology

Electrocardiographic changes in the acute hyperkalaemia produced by intragastri...

Charge-pump circuit in 65nm CMOS for neural stimulation on deep-brain stimulation

Inhibition of central angiotensin II-induced pressor responses by hydrogen pero...

Hydrogen peroxide (H2O2), important reactive oxygen species produced endogenously, may have different physiological actions. The superoxide anion (O2 •_) is suggested to be part of the signaling mechanisms activated by angiotensin II (ANG II) and central virus-mediated overexpression of the enzyme superoxide dismutase (that dismutates O2 •_ to H2O2) reduces pressor and dipsogenic responses to central ANG II. Wh...

Cardiovascular responses produced by central injection of hydrogen peroxide in ...

Reactive oxygen species (ROS) have been shown to modulate neuronal synaptic transmission and may play a role on the autonomic control of the cardiovascular system. In this study we investigated the effects produced by hydrogen peroxide (H2O2) injected alone or combined with the anti-oxidant agent N-acetil-l-cysteine (NAC) or catalase into the fourth brain ventricle (4th V) on mean arterial pressure and heart ra...

Central antioxidant therapy inhibits parasympathetic baroreflex control in cons...

Baroreceptor reflex is an important system for neural control of blood pressure. Recently, reactive oxygen species (ROS) have been shown to play an important role in neuronal activity of central areas related to blood pressure control. The aim of this study was to investigate the effects elicited by ascorbic acid (AAC) and N-acetylcysteine (NAC) injections into the 4thV on the parasympathetic component of the b...