2 documents found, page 1 of 1
Alterations in mucosa branched N-glycans lead to dysbiosis and downregulation o...
Rodrigues, Cláudia S.; Gaifem, Joana; Pereira, Márcia S.; Alves, Maria Francisca; Silva, Mariana; Padrão, Nuno; Cavadas, BrunoThe perturbation of the symbiotic relationship between microbes and intestinal immune system contributes to gut inflammation and Inflammatory Bowel Disease (IBD) development. The host mucosa glycans (glycocalyx) creates a major biological interface between gut microorganisms and host immunity that remains ill-defined. Glycans are essential players in IBD immunopathogenesis, even years before disease onset. Howe...
Early life exposures and the risk of inflammatory bowel disease: Systematic rev...
Agrawal, Manasi; Sabino, João; Frias-Gomes, Catarina; Hillenbrand, Christen M.; Soudant, Celine; Axelrad, Jordan E.; Shah, Shailja C.Background: Early life exposures impact immune system development and therefore the risk of immune-mediated diseases, including inflammatory bowel disease (IBD). We systematically reviewed the impact of pre-, peri‑, and postnatal exposures up to the age of five years on subsequent IBD diagnosis. Methods: We identified case-control and cohort studies reporting on the association between early life environmental ...