4 documents found, page 1 of 1
Topical treatment of experimental cutaneous leishmaniasis in golden hamster (Me...
Comandolli-Wyrepkowski, Claudia Dantas; Grafova, Iryna; Naiff, Maricleide de Farias; Avella, Maurizio; Gentile, Gennaro; Grafov, Andrèi AndriyCurrent treatment of cutaneous leishmaniasis (CL) relies mainly on pentavalent antimonials salts and second-line drugs include pentamidine and amphotericin B, but these therapies have side effects and require parenteral administration. The aim of this work was to evaluate the topical formulations containing pentamidine isethionate (PI) in the experimental treatment of cutaneous leishmaniasis (CL). Golden hamste...
Antileishmanial activity of extracts from Libidibia ferrea: development of in v...
Comandolli-Wyrepkowski, Claudia Dantas; Jensen, Bruno Bezerra; Grafova, Iryna; Santos, Pierre Alexandre dos; Barros, Angela Maria ComapaO tratamento da leishmaniose cutânea (LC) é de difícil resultado, devido ao escasso número de fármacos capazes de eliminar completamente a forma intracelular do parasita. No presente estudo, objetivou-se avaliar: i) propriedades fitoquímicas dos extratos de Libidibia ferrea; ii) a atividade antileishmania de extratos de L. ferrea contra promastigotas e amastigotas de Leishmania (Leishmania) amazonensis e Leishm...
Avaliação da atividade antileishmania in vitro de Tanacetum vulgare (Asteraceae)
Jensen, Bruno B; Comandolli-Wyrepkowski, Claudia Dantas; Barros, Angela M C; Soares, Fabiane V.; Grafova, Iryna; Grafov, Andriy
Evaluation of the in vitro antileishmania activity of Tanacetum vulgare (Astera...
Jensen, Bruno Bezerra; Comandolli-Wyrepkowski, Claudia Dantas; Barros, Angela Maria Comapa; Soares, Fabiane Veloso; Grafovac, Iryna; Grafov, AndriyLeishmaniasis is considered a neglected disease. In recent years studies have shown that several plants have activity against these pathogens, serving as the basis for the formulation of herbal medicines or as a target for obtaining active principles against the disease. This study aimed to evaluate the in vitro antileishmania biological activity of the hexanic and methanolic extracts of the flowers and leaves ...