7 documents found, page 1 of 1
Evaluation of ADAM10 levels and activity in different biological media
Peron, Rafaela; Vatanabe, Izabela Pereira; Manzine, Patricia Regina; Grigoli, Marina Mantellatto; Cominetti, Márcia ReginaAlzheimer's disease (AD) affects millions of people worldwide and results from two major pathological hallmarks, neurofibrillary tangles and senile plaques. The latter are derived from the cleavage of the amyloid precursor protein (APP) by the amyloidogenic pathway, which is avoided by the a-secretase ADAM10. This study aimed to evaluate ADAM10 levels and activity in different biological media of individuals w...
[10]-Gingerol improves doxorubicin anticancer activity and decreases its side e...
Cominetti, Márcia Regina
Polypyridyl ruthenium complexes : novel DNA-intercalating agents against human ...
Reis, João Paulo Barolli; Correa, Rodrigo de Souza; Miranda, Fabio da Silva; Ribeiro, Juliana Uema; Bloch Junior, Carlos; Ellena, Javier AlcidesThis paper describes a new series of four DNA-intercalating agents with promising anticancer activities, based on ruthenium(II) with the planar ligand dpqQX (dpqQX = dipyrido[3,2-a:2',3'-c]quinoxaline[2,3-b]quinoxaline). The complexes identified as trans-[RuCl2(dppb)(dpqQX)], cis-[RuCl2(dppb)(dpqQX)], ct-[RuCl(CO)(dppb)(dpqQX)]PF6 and ct-[RuCl2(PPh3)2(dpqQX)] (dppb = 1,4-bis(diphenylphosphine)butane and PPh3 = ...
Estudos dos efeitos de metaloproteases/desintegrinas isoladas do veneno da serp...
Cominetti, Márcia ReginaUniversidade Federal de Minas Gerais; This work presents the isolation and biological characterization of a novel metalloprotease/disintegrin, BaG, isolated from the Bothrops alternatus snake venom. BaG was purified in a two-step chromatographic model using Gelatin-Sepharose and DEAE-Sepharose resins. The molecular mass of purified protein was estimated by SDS-PAGE as approximately 130kDa under non-reducing con...
Ruthenium(II) complexes of 1,3-thiazolidine-2-thione : cytotoxicity against tum...
Correa, Rodrigo de Souza; Silva, Monize Martins da; Graminha, Angelica Ellen; Meira, Cássio Santana; Santos, Jamyle Andrade Ferreira dosThree newmixed and mononuclear Ru(II) complexes containing 1,3-thiazolidine-2-thione (tzdtH) were synthesized and characterized by spectroscopic analysis, molar conductivity, cyclic voltammetry, high-resolution electrospray ionization mass spectra and X-ray diffraction. The complexes presented unique stereochemistry and the proposed formulae are: [Ru(tzdt)(bipy)(dppb)]PF6 (1), cis-[Ru(tzdt)2(PPh3)2] (2) and tra...
Ru(II)-based complexes with N-(acyl)-N′,N′-(disubstituted)thiourea ligands : sy...
Correa, Rodrigo de Souza; Oliveira, Katia Mara de; Delolo, Fábio Godoy; Alvarez Hernández, Anislay; Mocelo, Raúl; Plutin, Ana M.Four ruthenium(II)-based complexeswith N-(acyl)-N′,N′-(disubstituted)thiourea derivatives (Th)were obtained. The compounds, with the general formula trans-[Ru(PPh3)2(Th)(bipy)]PF6, interact with bovine serum albumin (BSA) and DNA. BSA-binding constants, which were in the range of 3.3–6.5 × 104 M−1, and the thermodynamic parameters (ΔG, ΔH and ΔS), suggest spontaneous interactions with this protein by electrosta...
Estudo do sistema imune do camarão branco Litopenaeus schmitti (Crustacea: Deca...
Cominetti, Márcia ReginaDissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Agrárias.; Este trabalho teve como objetivo o estudo do sistema imune do camarão branco Litopenaeus schmitti, enfatizando as aglutininas/lectinas plasmáticas. O soro apresentou atividade aglutinante contra uma variedade de eritrócitos. Esta atividade caracterizou-se por ser parcialmente dependente de cálcio, termosensível e pouc...