10 documents found, page 1 of 1
Brazilian Consensus for the Treatment of Multiple Sclerosis: Brazilian Academy ...
Marques,Vanessa Daccach; Passos,Giordani Rodrigues dos; Mendes,Maria Fernanda; Callegaro,Dagoberto; Lana-Peixoto,Marco AurélioABSTRACT The expanding therapeutic arsenal in multiple sclerosis (MS) has allowed for more effective and personalized treatment, but the choice and management of disease-modifying therapies (DMTs) is becoming increasingly complex. In this context, experts from the Brazilian Committee on Treatment and Research in Multiple Sclerosis and the Neuroimmunology Scientific Department of the Brazilian Academy of Neurolo...
Guideline for multiple sclerosis treatment in Brazil: Consensus from the Neuroi...
Comini-Frota,Elizabeth Regina; Vasconcelos,Cláudia C. F.; Mendes,Maria FernandaABSTRACT Multiple sclerosis has become an ever-increasing challenge to neurologists. With the release of the latest medications on the market, Brazilian neurologists feel divided between following their patients’ evolution in accordance with the strict rules established by the Brazilian Ministry of Health regarding drug distribution, or following disease progression and worsening in accordance with the evidence...
Cerebrum-cervical arterial dissection in adults during sports and recreation
Fragoso,Yara Dadalti; Adoni,Tarso; Amaral,Lazaro Luiz Faria do; Braga,Flavio Tulio; Brooks,Joseph Bruno Bidin; Campos,Christiane SiqueiraDissection of cervical arteries constitutes a medical emergency. Although relatively rarely, activities classified as sports and recreation may be a cause of arterial dissection independently of neck or head trauma. The purpose of the present paper was to present a series of cases of cerebrum-cervical arterial dissection in individuals during or soon after the practice of these sports activities. Methods Retros...
Clinical profile of patients with myasthenia gravis followed at the University ...
Mourão,Aline Mansueto; Barbosa,Luiz Sérgio Mageste; Comini-Frota,Elizabeth Regina; Freitas,Denise da Silva; Gomez,Rodrigo Santiago; Burns,Ted M.Summary Objective: to determine the clinical profile of patients with myasthenia gravis (MG); followed at the Neuromuscular Diseases Clinic of the University Hospital, Federal University of Minas Gerais, Brazil, and to compare it with other Brazilian case series. Methods: sociodemographic and clinical data were collected from patients, and a systematic literature review performed, focusing on national studies o...
Supplementation and therapeutic use of vitamin D in patients with multiple scle...
Brum,Doralina Guimarães; Comini-Frota,Elizabeth Regina; Vasconcelos,Claúdia Cristina F.; Dias-Tosta,ElzaMultiple sclerosis (MS) is an inflammatory, autoimmune, demyelinating, and degenerative central nervous system disease. Even though the etiology of MS has not yet been fully elucidated, there is evidence that genetic and environmental factors interact to cause the disease. Among the main environmental factors studied, those more likely associated with MS include certain viruses, smoking, and hypovitaminosis D. ...
Natalizumab adverse events are rare in patients with multiple sclerosis
Fragoso,Yára Dadalti; Alves-Leon,Soniza Vieira; Arruda,Walter Oleschko; Carvalho,Margarete de Jesus; Comini-Frota,Elizabeth Regina; Corrêa,Éber CastroObjective To assess the prevalence and the profile of adverse events (AE) of natalizumab in patients with multiple sclerosis (MS). Methods Data collection from neurologists attending to patients with MS at specialized units in Brazil. Results Data from 103 patients attending the infusion centers of 16 MS units in 9 Brazilian states were included in the study. The total number of infusions was 1,042. Seventy-nin...
Multiple sclerosis in South America: month of birth in different latitudes does...
Fragoso,Yara Dadalti; Adoni,Tarso; Almeida,Sandra Maria Garcia de; Alves-Leon,Soniza Vieira; Arruda,Walter Oleschko; Barbagelata-Aguero,FiorellaObjective To assess whether the month of birth in different latitudes of South America might influence the presence or severity of multiple sclerosis (MS) later in life. Methods Neurologists in four South American countries working at MS units collected data on their patients' month of birth, gender, age, and disease progression. Results Analysis of data from 1207 MS patients and 1207 control subjects did not s...
Nearly one-half of Brazilian patients with multiple sclerosis using natalizumab...
Fragoso,Yara Dadalti; Mendes,Maria Fernanda; Arruda,Walter Oleschko; Becker,Jefferson; Brooks,Joseph Bruno Bidin; Carvalho,Margarete de JesusObjective Natalizumab is a new and efficient treatment for multiple sclerosis (MS). The risk of developing progressive multifocal leukoencephalopathy (PML) during the use of this drug has created the need for better comprehension of JC virus (JCV) infection. The objective of the present study was to assess the prevalence of JCV-DNA in Brazilian patients using natalizumab. Method Qualitative detection of the JCV...
Multiple sclerosis starting before the age of 18 years: the Brazilian experience
Fragoso,Yara Dadalti; Ferreira,Maria Lucia Brito; Morales,Nivea de Macedo Oliveira; Arruda,Walter Oleschko; Brooks,Joseph Bruno BidinMultiple sclerosis (MS) starting in childhood and adolescence poses a challenge for diagnosis and management of the disease. The aim of the present study was to assess the characteristics of early onset MS in Brazilian patients. Methods Retrospective data collection from specialized MS units. Results From 20 MS units in 11 Brazilian states, 117 cases of MS starting before the age of 18 years were collected. The...
Pregnancy and multiple sclerosis: the initial results from a Brazilian database
Fragoso,Yara Dadalti; Finkelsztejn,Alessandro; Comini-Frota,Elizabeth Regina; Gama,Paulo Diniz da; Grzesiuk,Ansderson KuntzPURPOSE: Pregnancy management poses an extra challenge to physicians and their multiple sclerosis (MS) patients. There are few papers reporting databases on the subject. METHOD: Brazilian database from nine MS clinical and research units, with complete data on 47 pregnant women (49 pregnancies). RESULTS: Despite relatively high exposure to MS medications, no birth defects were reported. Low birth weight and pre...