5 documents found, page 1 of 1
Cost effectiveness of outpatient lumbar discectomy
Linhares, D; Fonseca, JA; Ribeiro-da-Silva, M; Conceição, F; Sousa, A; Sousa-Pinto, B; Neves, NBackground: Microdiscectomy is the most commonly performed spine surgery and the first transitioning for outpatient settings. However, this transition was never studied, in what comes to cost-utility assessment. Accordingly, this economic study aims to access the cost-effectiveness of outpatient lumbar microdiscectomy when compared with the inpatient procedure. Methods: This is a cost utility study, adopting th...
Sympathetic activity in breast cancer and metastasis: partners in crime
Conceição, F; Sousa, DM; Paredes, J; Lamghari, MThe vast majority of patients with advanced breast cancer present skeletal complications that severely compromise their quality of life. Breast cancer cells are characterized by a strong tropism to the bone niche. After engraftment and colonization of bone, breast cancer cells interact with native bone cells to hinder the normal bone remodeling process and establish an osteolytic “metastatic vicious cycle”. The...
Nociceptive mechanisms driving pain in a post-traumatic osteoarthritis mouse model
Alves, CJ; Couto, M; Sousa, DM; Magalhães, A; Neto, E; Leitão, L; Conceição, F; Monteiro, AC; Ribeiro-da-Silva, M; Lamghari, MIn osteoarthritis (OA), pain is the dominant clinical symptom, yet the therapeutic approaches remain inadequate. The knowledge of the nociceptive mechanisms in OA, which will allow to develop effective therapies for OA pain, is of utmost need. In this study, we investigated the nociceptive mechanisms involved in post-traumatic OA pain, using the destabilization of the medial meniscus (DMM) mouse model. Our resu...
The Mechanisms Underlying the Biological Response to Wear Debris in Periprosthe...
Couto, M; Vasconcelos, DP; Sousa, DM; Sousa, B; Conceição, F; Neto, E; Lamghari, M; Alves, CJJoint replacement surgery is the gold-standard therapeutic approach to treat patients with end-stage hip and knee arthritis, providing pain relief and joint function recovery. Despite the improvements in implant design and surgical techniques, revisions after total joint replacement are expected to grow. The periprosthetic inflammation, featured by the sustained inflammatory response to the implant debris, elic...
Osteoblasts are inherently programmed to repel sensory innervation
Leitão, L; Neto, E; Conceição, F; Monteiro, AC; Couto, M; Alves, CJ; Sousa, DM; Lamghari, MTissue innervation is a complex process controlled by the expression profile of signaling molecules secreted by tissue-resident cells that dictate the growth and guidance of axons. Sensory innervation is part of the neuronal network of the bone tissue with a defined spatiotemporal occurrence during bone development. Yet, the current understanding of the mechanisms regulating the map of sensory innervation in th...