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Inhibitory effect of vinegars on the formation of polycyclic aromatic hydrocarb...

Cordeiro, T; Viegas, Olga; Silva, M; Martins, ZE; Fernandes, I; Ferreira, Isabel; Pinho, Olívia; Nuno Mateus; Conceicao Calhau

The effect of five different vinegars, applied as a seasoning, on the formation of polycyclic aromatic hydrocarbons (PAH) in charcoal-grilled pork loin was investigated. PAH were assayed using acetonitrile based-extraction and high-performance liquid chromatography with fluorescence detection. Unseasoned samples presented a mean value of 31.47 ng g(-1) of PAH4 (sum of benz[a] anthracene, chrysene, benzo[b]fluor...


Effects of environmental pollutants on MCF-7 Cells: A metabolic approach

Norberto, Sónia; Conceicao Calhau; Pestana, Diogo; Faria, Ana

Several environmental pollutants (EPs) have been associated with biological and molecular processes leading to adverse human health effects, including different types of cancer. Nevertheless, the effects exerted on tumor glucose metabolism are unclear. To evaluate the effects on cellular and molecular mechanisms, namely glucose metabolism, MCF-7 cells were exposed to EPs during short- and long-term exposures. T...


Pharmacokinetics of blackberry anthocyanins consumed with or without ethanol: A...

Marques, Claúdia; Iva Fernandes; Norberto, Sónia; Sá-Couto CD; Teixeira, Diana; Freitas, Victor de; Nuno Mateus; Conceicao Calhau; Faria, Ana

Scope: This study was designed to evaluate the influence of ethanol on the bioavailability of blackberry anthocyanins. Methods and results: A total of 18 participants were recruited to consume 250 mL of a blackberry puree (650 mg of anthocyanins) without (BBP) or with 12% ethanol (BBP 12%). Venous blood was collected from participants at baseline and at 15, 30, 60, and 120 min after puree ingestion. Urine sampl...


Alimentação e nutrição na gravidez

Teixeira, D.; Pestana, D.; Conceicao Calhau; Vicente, L.; Graça, Pedro


Effects of Environmental Organochlorine Pesticides on Human Breast Cancer: Puta...

Diogo Pestana; Diana Teixeira; Ana Faria; Valentina Domingues; Rosario Monteiro; Conceicao Calhau

Human exposure to persistent organic pollutants (POPs) is a certainty, even to long banned pesticides like o,p-dichlorodiphenyltrichloroethane (o,p-DDT), and its metabolites p,p-dichlorodiphenyldichloroethylene (p,p-DDE), and p,p-dichlorodiphenyldichloroethane (p,p-DDD). POPs are known to be particularly toxic and have been associated with endocrine-disrupting effects in several mammals, including humans even a...


Inflammatory and Cardiometabolic Risk on Obesity: Role of Environmental Xenoest...

Diana Teixeira; Diogo Pestana; Cristina Santos; Luisa Correia Sa; Claudia Marques; Sonia Norberto; Manuela Meireles; Ana Faria; Ricardo Silva; Gil Faria

Context: Some chemicals used in consumer products or manufacturing (eg, plastics, pesticides) have estrogenic activities; these xenoestrogens (XEs) may affect immune responses and have recently emerged as a new risk factors for obesity and cardiovascular disease. However, the extent and impact on health of chronic exposure of the general population to XEs are still unknown. Objective: The objective of the study...


Ervas aromáticas: uma estratégia para a redução de sal na alimentação dos portu...

Lopes, A.; Teixeira, D.; Conceicao Calhau; Pestana, D.; Padrão, Patrícia; Graça, Pedro


Linhas de orientação sobre contaminantes de alimentos

Teixeira, D.; Pestana, D.; Conceicao Calhau; Graça, Pedro


Endocrine Disruptor DDE Associated with a High-Fat Diet Enhances the Impairment...

Luis M Rodriguez Alcala; Carla Sa; Ligia L Pimentel; Diogo Pestana; Diana Teixeira; Ana Faria; Conceicao Calhau; Ana Gomes

The banned pesticide dichlorodiphenyltrichloroethane (DDT) and its main metabolite, p,p'-dichlorodiphenyldichloroethylene (DDE), are commonly found in the food chain and in all tissues of living organisms. DDE is associated with metabolic diseases acting as an endocrine disruptor and more recently with the obesity pandemic. This study focuses on using fatty acid analysis to relate DDE exposure and metabolic dys...


Interplay between Anthocyanins and Gut Microbiota

Ana Faria; Iva Fernandes; Sonia Norberto; Nuno Mateus; Conceicao Calhau

Anthocyanins are naturally occurring compounds abundant in the human diet. Evidence has accumulated regarding the positive association of their intake with healthy biological effects. The microbiota has just been started to be considered as a metabolic organ, hence contributing to the metabolism of phenolic compounds and, consequently, to their bioavailability and the biological effects displayed by them. This ...


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