85 documents found, page 1 of 9
Engineered biomimetic cisplatin-polyphenol nanocomplex for chemo-immunotherapy ...
Hao, Xinyan; Tang, Yucheng; Xu, Wenjie; Wang, Ming; Liu, Jiayi; Li, Yongjiang; He, Jun; Peng, Yanjin; Sun, Pengcheng; Liao, Dehua; Hu, Xiongbin© 2025. The Author(s).; Glioblastoma multiforme (GBM) is characterized by pronounced immune escape and resistance to chemotherapy-induced apoptosis. Preliminary investigations revealed a marked overexpression of gasdermin E (GSDME) in GBM. Notably, cisplatin (CDDP) demonstrated a capacity of inducing pyroptosis by activating caspase-3 to cleave GSDME, coupled with the release of proinflammatory factors, indicat...
Characterising acute and chronic care needs
Zuniga, Yves Miel H.; Zumla, Alimuddin; Zuhlke, Liesl J.; Zoladl, Mohammad; Ziaeian, Boback; Zhong, Chenwen; Zhao, Xiu Ju George; Zhang, Zhi JiangFunding Information: This research was funded by The Leona M. and Harry B. Helmsley Charitable Trust as part of the Addressing the Challenge and Constraints of Insulin Sources and Supply (ACCISS) Study. Statements and conclusions presented in this report are those of the authors alone and do not necessarily reflect the views of the Helmsley Charitable Trust. All references and conclusions are intended for educa...
Rational Design of Metal-Organic Frameworks for Pancreatic Cancer Therapy
Melle, Francesca; Menon, Dhruv; Conniot, João; Ostolaza-Paraiso, Jon; Mercado, Sergio; Oliveira, Jhenifer; Chen, Xu; Mendes, Bárbara B; Conde, João© 2025 The Author(s). Advanced Materials published by Wiley‐VCH GmbH.; Despite improvements in cancer survival rates, metastatic and surgery-resistant cancers, such as pancreatic cancer, remain challenging, with poor prognoses and limited treatment options. Enhancing drug bioavailability in tumors, while minimizing off-target effects, is crucial. Metal-organic frameworks (MOFs) have emerged as promising drug de...
Enzyme-responsive vitamin D-based micelles for paclitaxel-controlled delivery a...
Peixoto, Diana; Ravasco, João M. J. M.; Blanco Fernandez, Barbara; Veiga, Francisco; Concheiro, Angel; Conde, João; Paiva-Santos, Ana CláudiaPublisher Copyright: © 2025 The Authors; Pancreatic ductal adenocarcinoma (PDAC) remains one of the most feared diseases worldwide owing to its poor prognosis, negligible therapeutic advances, and high mortality. Herein, multifunctional enzyme-responsive micelles for the controlled delivery of paclitaxel (PTX) were prepared to circumvent its current clinical challenges. Accordingly, two enzyme-responsive struct...
Translating nanomedicines from the lab to the clinic
Herrmann, Inge; Li, Zhong Alan; Bahal, Raman; Conde, JoãoPublisher Copyright: © 2024 The Author(s); The literature is replete with ingenious examples of nanomaterials engineered to address biomedical challenges. These materials may act as diagnostic agents, deliver active therapeutic agents, or intervene directly through a variety of modalities such as photothermal therapy. But the translation of such materials to the clinic remains uncommon.
Changing life expectancy in European countries 1990–2021
Steel, Nicholas; Bauer-Staeb, Clarissa Maria Mercedes; Ford, John A.; Abbafati, Cristiana; Abdalla, Mohammed Altigani; Abdelkader, Atef; Abdi, ParsaFunding Information: The research reported in this publication was funded by the Gates Foundation. Publisher Copyright: © 2025 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license; Background: Decades of steady improvements in life expectancy in Europe slowed down from around 2011, well before the COVID-19 pandemic, for reasons which remain disputed. We aimed to a...
Longan-inspired chitosan-pectin core-shell hydrogel beads for oral delivery of ...
Phan, V. H.Giang; Nguyen, Bich Phuong Thi; Nguyen, Nhi Yen; Tran, Cam Nhung Dinh; Nguyen, Quynh Nhu Doan; Luu, Cuong Hung; Manivasagan, PanchanathanFunding Information: This work was supported by Ton Duc Thang University. This work was also supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (NRF-2023R1A2C1005904). E.-S.J. is incredibly grateful for the research grant from the Korean Ministry of Education, Science & Technology (2016R1D1A3B0201175615), the Korean Health Technology R&D Project (HP23C0260)...
Exploring the link between low germline mutational load and low breast cancer i...
Rueff, Jose; Conde, João; Castro, GuilhermeFunding Information: J.C. acknowledges the European Research Council (ERC) under the European Union's Horizon 2020 Research and Innovation Program ( ERC-StG-2019-848325 ). JR and JC acknowledge the financial support from grants UIDP/BIM/0009/2020 (DOI 10.54499/UIDP/00009/2020 ) and UIDB/BIM/0009/2020 (DOI 10.54499/UIDB/00009/2020) from the Portuguese Foundation for Science and Technology (FCT) to the Center for...
Age-sex-specific burden of urological cancers attributable to risk factors in C...
Xue, Mingyang; Guo, Weiheng; Zhou, Yundong; Meng, Jialin; Xi, Yong; Pan, Liming; Ye, Yanfang; Zeng, You; Che, Zhifei; Zhang, Liang; Ye, PengpengPublisher Copyright: © 2025 The Author(s); Background: As global aging intensifies, urological cancers pose increasing health and economic burdens. In China, home to one-fifth of the world's population, monitoring the distribution and determinants of these cancers and simulating the effects of health interventions are crucial for global and national health. Methods: With Global Burden of Disease (GBD) China dat...
Conductive polymers in smart wound healing
Jiang, Yanhua; Zhou, Yongjian; Tian, Yu; Nabavi, Noushin; Ashrafizadeh, Milad; Conde, João; Li, Zhe; Guo, LiangPublisher Copyright: © 2025 The Authors; Wound healing, particularly in particularly after surgical operations and especially cardiothoracic surgeries, presents a significant global healthcare burden due to prolonged recovery time, recurrent infections, and limited effectiveness of the conventional therapies. The recent advancements in biomaterials have positioned conductive polymers (CPs) as promising componen...