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Dual modulation of cytotoxic and checkpoint receptors tunes the efficacy of ado...
Blanco Dominguez, Rafael; Barros, Leandro; Carreira, Mariana; van der Ploeg, Manon; Condeço, Carolina; Marsères, Gabriel; Ferreira, CristinaColorectal cancer (CRC) remains a challenge for current immunotherapies. Vδ1+ γδ T cells offer a promising alternative because of their HLA-I-independent cytotoxicity and natural tissue tropism. We developed Delta One T (DOT) cells, a Vδ1+ γδ T cell-based adoptive cell therapy clinically explored for hematological malignancies but not yet for solid tumors. Here we demonstrate the capacity of DOT cells to target...
CD155/PVR determines acute myeloid leukemia targeting by Delta One T cells
Mensurado, Sofia; Condeço, Carolina; Sánchez-Martínez, Diego; Shirley, Sara; Coelho, Rui; Tirado, Néstor; Vinyoles, Meritxell; Blanco Dominguez, RafaelRelapsed or refractory acute myeloid leukemia (AML) remains a major therapeutic challenge. We have recently developed a Vδ1+ γδ T cell-based product for adoptive immunotherapy, named Delta One T (DOT) cells, and demonstrated their cytolytic capacity to eliminate AML cell lines and primary blasts in vitro and in vivo. However, the molecular mechanisms responsible for the broad DOT-cell recognition of AML cells r...