1 document found, page 1 of 1
Sort by
Issue Date
Carbidopa alters tryptophan metabolism in breast cancer and melanoma cells lead...
Duarte, D; Amaro, F; Silva, I; Silva, D; Fresco, P; Oliveira, JC; Reguengo, H; Gonçalves, J; Vale, NCarbidopa is used for the treatment of Parkinson’s disease (PD) as an inhibitor of DOPA decarboxylase, and PD patients taking carbidopa have a lower incidence of various tumors, except for breast cancer andmelanoma. Recently, itwas shown that carbidopa inhibits tryptophan-2,3-dioxygenase (TDO) and kynureninase enzymes. In the present study, the effect of carbidopa on the viability and metabolic profile of breas...
Date: 2019
|
Origin: Repositório Aberto da Universidade do Porto