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Inhibition of receptor-interacting protein kinase 1 improves experimental non-a...

Majdi, Amine; Aoudjehane, Lynda; Ratziu, Vlad; Islam, Tawhidul; Afonso, Marta B; Conti, Filomena; Mestiri, Taïeb; Lagouge, Marie; Foufelle, Fabienne

In non-alcoholic fatty liver disease (NAFLD), hepatocytes can undergo necroptosis: a regulated form of necrotic cell death mediated by the receptor-interacting protein kinase (RIPK) 1. Herein, we assessed the potential for RIPK1 and its downstream effector mixed lineage kinase domain-like protein (MLKL) to act as therapeutic targets and markers of activity in NAFLD.

Date: 2020   |   Origin: Estudo Geral - Universidade de Coimbra
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