3 documents found, page 1 of 1
Retention of minerals, antioxidants, pigments, and glucosinolates by broccoli f...
Ribeiro, Vânia S.; Cruz, Pedro F.; Almeida, Zaida L.; Silva, Cândida G.; Silva, Maria Isabel; Silva, Inês S.; Santos, Liliana R.; Santos, Marta T.Given the poor palatability and chewability of crude green bean pods (Phaseolus vulgaris) and broccoli florets (Brassica oleracea var. italica Plenck) these vegetables are generally microwaved, steamed or water boiled. Hence, here, we evaluated the contents of minerals, antioxidants, phenolics, glucosinolates, pigments, colour, texture and flavour of water-boiling broccoli and green bean pods, with four mineral...
NS1 protein as a novel anti-influenza target: Map-and-mutate antiviral rational...
Trigueiro-Louro, João; Santos, Luís A.; Almeida, Filipe; Correia, Vanessa; Brito, Rui M.M.; Rebelo-de-Andrade, HelenaInfluenza NS1 is a promising anti-influenza target, considering its conserved and druggable structure, and key function in influenza replication and pathogenesis. Notwithstanding, target identification and validation, strengthened by experimental data, are lacking. Here, we further explored our previously designed structure-based antiviral rationale directed to highly conserved druggable NS1 regions across a br...
To hit or not to hit: large-scale sequence analysis and structure characterizat...
Trigueiro-Louro, João M.; Correia, Vanessa; Santos, Luís A.; Guedes, Rita C.; Brito, Rui M.M.; Rebelo-de-Andrade, HelenaInfluenza NS1 protein is among the most promising novel druggable anti-influenza target, based on its structure; multiple interactions; and global function in influenza replication and pathogenesis. Notwithstanding, drug development guidance based on NS1 structural biology is lacking. Here, we design a promising strategy directed to highly conserved druggable regions as a result of an exhaustive large-scale seq...