4 documents found, page 1 of 1
Identifying new isatin derivatives with GSK-3 inhibition capacity through molec...
Britto, Karolinni B.; Francisco, Carla S.; Ferreira, Débora; Borges, Bárbara J. P.; Conti, Raphael; Profeti, Demetrius; Rodrigues, L. R.The semi-synthesis of 11 isatin derivatives was achieved through bimolecular nucleophilic substitution and click chemistry. Seven new compounds were obtained. All chemical structures were determined by infrared spectroscopy (IR), nuclear magnetic resonance spectrometry (NMR) and high-resolution mass spectrometry (HRMS) data. These derivatives were evaluated for their anti-GSK-3 activity and all isatin derivativ...
Bioactive extracts and chemical constituents of two endophytic strains of Fusar...
Nascimento, Andréa Mendes do; Conti, Raphael; Turatti, Izabel Cristina Casanova; Cavalcanti, Bruno Coêlho; Lotufo, Leticia Veras Costa; Pessoa, CláudiaEthyl acetate extracts of cultures grown in liquid Czapek and on solid rice media of the fungal endophyte Fusarium oxysporum SS46 isolated from the medicinal plant Smallanthus sonchifolius (Poepp.) H. Rob., Asteraceae, exhibited considerable cytotoxic activity when tested in vitro against human cancer cells. Chromatographic separation yielded anhydrofusarubin (1) and beauvericin (2) that were identified based o...
Diversidade e atividade antimicrobiana de microrganismos endofíticos da planta ...
Conti, RaphaelConselho Nacional de Desenvolvimento Científico e Tecnológico; Microrganismos endofíticos vivem intra e/ou intercelularmente em plantas hospedeiras, sem causar danos aparentes e são de grande importância biotecnológica para a indústria, agricultura e medicina. A planta medicinal Borreria verticillata, conhecida popularmente como vassourinha-de-botão é utilizada no tratamento de infecções e inflamações, além de ...
Mycoleptones A−C and polyketides from the endophytem mycoleptodiscus indicus
Andrioli, Willian J.; Conti, Raphael; Araújo, Magali J.; Zanasi, Riccardo; Cavalcanti, Bruno C.; Manfrim, Viviane; Toledo, Juliano S.; Tedesco, DanieleThree new azaphilones with an unusual methylene bridge, named mycoleptones A, B, and C (2, 4, and 5), were isolated from cultures of Mycoleptodiscus indicus, a fungus associated with the South American medicinal plant Borreria verticillata. Additionally, four known polyketides, austdiol (1), eugenitin (3), 6-methoxyeugenin (6), and 9- hydroxyeugenin (7), were also isolated. The structural characterization of co...