5 documents found, page 1 of 1
Identifying New Isatin Derivatives with GSK-3β Inhibition Capacity through Mole...
Britto,Karolinni B.; Francisco,Carla S.; Ferreira,Débora; Borges,Bárbara J. P.; Conti,Raphael; Profeti,Demetrius; Rodrigues,Ligia R.The semi-synthesis of 11 isatin derivatives was achieved through bimolecular nucleophilic substitution and click chemistry. Seven new compounds were obtained. All chemical structures were determined by infrared spectroscopy (IR), nuclear magnetic resonance spectrometry (NMR) and high-resolution mass spectrometry (HRMS) data. These derivatives were evaluated for their anti-GSK-3b activity and all isatin derivati...
In vitro Antiplasmodial Activities of Alkaloids Isolated from Roots of Worsleya...
Gonring-Salarini,Karla L.; Conti,Raphael; Andrade,Jean Paulo de; Borges,Bárbara Juliana P.; Aguiar,Anna Caroline C.; Souza,Juliana O. deA combined phytochemical, crystallographic and biological study of Worsleya procera roots was performed. Fifteen alkaloids were identified by gas chromatography mass spectrometry (GC-MS) and seven of them were isolated. The structures of the alkaloids were elucidated by spectroscopic methods, and a detailed crystallographic study of tazettine was carried out. The isolated alkaloids and the obtained extracts wer...
Antibacterial, antifungal and cytotoxic activities exhibited by endophytic fung...
Felício,Rafael de; Pavão,Gabriel B.; Oliveira,Ana Lígia L. de; Erbert,Cíntia; Conti,Raphael; Pupo,Monica T.; Furtado,Niege A.J.C.; Ferreira,Elthon G.Abstract Marine environment is one of the most important sources regarding natural products research. Besides, marine microorganisms have been denominated as a talented natural source for discovery of new leads. Although the association of macroalgae and fungi has been described regarding ecological issues, there is a lack of studies about marine seaweed endophytic fungi. In this context, the goal of this study...
Bioactive extracts and chemical constituents of two endophytic strains of Fusar...
Nascimento,Andréa M. do; Conti,Raphael; Turatti,Izabel C. C.; Cavalcanti,Bruno C.; Costa-Lotufo,Letícia V.; Pessoa,Cláudia; Moraes,Manoel O. deEthyl acetate extracts of cultures grown in liquid Czapek and on solid rice media of the fungal endophyte Fusarium oxysporum SS46 isolated from the medicinal plant Smallanthus sonchifolius (Poepp.) H. Rob., Asteraceae, exhibited considerable cytotoxic activity when tested in vitro against human cancer cells. Chromatographic separation yielded anhydrofusarubin (1) and beauvericin (2) that were identified based o...
Analysis of 16S rRNA and mxaF genes reveling insights into Methylobacterium nic...
Dourado,Manuella Nóbrega; Andreote,Fernando Dini; Dini-Andreote,Francisco; Conti,Raphael; Araújo,Janete Magali; Araújo,Welington LuizThe genus Methylobacterium comprises pink-pigmented facultative methylotrophic (PPFM) bacteria, known to be an important plant-associated bacterial group. Species of this group, described as plant-nodulating, have the dual capacity of producing cytokinin and enzymes, such as pectinase and cellulase, involved in systemic resistance induction and nitrogen fixation under specific plant environmental conditions. Th...