11 documents found, page 1 of 2
Thiopurines have no impact on outcomes of Crohn's disease patients beyond 12 mo...
Sousa, Paula; Patita, Marta; Arroja, Bruno; Lago, Paula; Rosa, Isadora; Sousa, Helena Tavares; Ministro, Paula; Mocanu, Irina; Vieira, AnaThe emergence of new treatments the inflammatory bowel diseases (IBD) raised questions regarding the role of older agents, namely thiopurines. Aims: To clarify the benefits of combination treatment with thiopurines on Crohn's disease (CD) patients in the maintenance phase of infliximab. Methods: In this analysis of the 2 -year prospective multicentric DIRECT study, patients were assessed in terms of clinical ac...
Prognostic value of hyperlactatemia in infected patients admitted to intensive ...
Silva, Catarina Mendes; Baptista, João Pedro; Mergulhão, Paulo; Froes, Filipe; Gonçalves-Pereira, João; Pereira, José Manuel; Dias, Claudia CamilaObjective: To evaluate the influence of patient characteristics on hyperlactatemia in an infected population admitted to intensive care units and the influence of hyperlactatemia severity on hospital mortality. Methods: A post hoc analysis of hyperlactatemia in the INFAUCI study, a national prospective, observational, multicenter study, was conducted in 14 Portuguese intensive care units. Infected patients admi...
Comparing the continuous geboes score with the Robarts Histopathology Index: de...
Magro, Fernando; Lopes, Joanne; Borralho, Paula; Lopes, Susana; Coelho, Rosa; Cotter, Jose; de Castro, Francisca Dias; Sousa, Helena TavaresBackground and Aims: The histological status of ulcerative colitis [UC] patients in clinical and endoscopic remission has gained space as an important prognostic marker and a key component of disease monitoring. Our main aims were to compare two histological indexes-the continuous Geboes score [GS] and the Robarts Histopathology index [RHI]-regarding their definitions of histological remission and response, and...
Sexual quality of life in inflammatory bowel disease: A multicenter, national-l...
Roseira, Joana; Magro, Fernando; Fernandes, Samuel; Simoes, Carolina; Portela, Francisco; Vieira, Ana Isabel; Patita, Marta; Leal, Carina; Lago, PaulaBackground: The impact of inflammatory bowel disease (IBD) on sexual health is a leading concern among patients. Most studies focus on sexual dysfunction rather than patient-perceived sexual quality of life (SQoL). We aimed to assess SQoL in IBD patients compared with healthy controls. Methods: This is a multicenter, cross-sectional study of IBD patients (n = 575 with Crohn's disease and n = 294 with ulcerative...
Transmural histological scoring systems in Crohn's Disease: A systematic review...
Sousa, Helena Tavares; Estevinho, Maria Manuela; Peyrin-Biroulet, Laurent; Danese, Silvio; Dias, Claudia Camila; Carneiro, Fatima; Magro, FernandoBackground: The relative proportion of inflammation and fibrosis in a stricture is highly relevant in defining the clinical approach for Crohn's disease [CD] patients. Whereas transmural inflammation in CD can be accurately estimated by cross-sectional imaging, evaluating the extent and severity of fibrosis still requires surgical pathology of intestinal resection specimens.This study systematically reviewed al...
Serum dipeptidyl peptidase 4: a predictor of disease activity and prognosis in ...
Pinto-Lopes, Pedro; Afonso, Joana; Pinto-Lopes, Rui; Rocha, Catia; Lago, Paula; Goncalves, Raquel; Sousa, Helena Tavares; Macedo, GuilhermeBackground: Serum dipeptidyl peptidase 4 (DPP-4) has drawn particular interest as a biomarker in inflammatory bowel disease (IBD), as this protease inactivates several peptides that participate in the inflammatory cascade. Methods: Two prospectively recruited cohorts consisting of 195 patients (101 had Crohn’s disease [CD] and 94 had ulcerative colitis [UC]) were evaluated using clinical indexes and followed up...
Waiting for ICU admission may increase the risk of death-A plea for better reso...
Castro, Silvia; Pereira, Isabel Jesus; Dias, Claudia Camila; Granja, CristinaBackground Mortality is high in critically ill patients. In order to study the risk factors associated with mortality in these patients, we conducted an observational retrospective study in the general Intensive Care Unit (ICU) of Faro Hospital. Methods All patients discharged from the general ICU in the year 2015 were evaluated for inclusion. Mortality was characterized in the first 48 hours of ICU stay, at th...
Comparison of different histological indexes in the assessment of UC activity a...
Magro, Fernando; Lopes, Joanne; Borralho, Paula; Lopes, Susana; Coelho, Rosa; Cotter, Jose; de Castro, Francisca Dias; Sousa, Helena TavaresObjective Histological remission is being increasingly acknowledged as a therapeutic endpoint in patients with UC. The work hereafter described aimed to evaluate the concordance between three histological classification systems-Geboes Score (GS), Nancy Index (NI) and RobartsHistopathologyIndex (RHI), as well as to evaluate their association with the endoscopic outcomes and the faecal calprotectin (FC) levels. D...
Is it possible to “find space for mental health” in young people? effectiveness...
Campos, Luísa; Dias, Pedro; Duarte, Ana; Veiga, Elisa; Dias, Claudia Camila; Palha, FilipaLack of knowledge regarding, and the stigma associated with, mental disorders have been identified as major obstacles for the promotion of mental health and early intervention. The present study aimed to evaluate the effectiveness of a school-based intervention program focused on the promotion of mental health literacy (MHL) in young people (“Finding Space for Mental Health”). A sample of 543 students (22 class...
Therapeutic drug monitoring of CT-P13: a comparison of four different immunoassays
Afonso, Joana; de Sousa, Helena Tavares; Rosa, Isadora; Carvalho, João; Dias, Claudia Camila; Magro, FernandoBackground: The commercialization of CT-P13, an infliximab (IFX) biosimilar, has the potential to decrease health-related costs and enhance access to biological therapies. This study aimed to address the accuracy and inter-assay agreement of the CT-P13 quantification using four different assays initially developed to assess IFX. Methods: The four different methods, one in-house method and three commercially ava...