9 documents found, page 1 of 1
Prognostic factors in patients with advanced differentiated thyroid cancer trea...
Treistman,Natalia; Nobre,Gabriela Maia; Tramontin,Mariana Yoshii; Silva,Gabriel Madeira Werberich da; Herchenhorn,Daniel; Araujo,Luiz Henrique de LimaABSTRACT Objective: The aim of this study was to describe the real-world experience multikinase inhibitors (MKI) in the treatment advanced differentiated thyroid carcinoma (DTC) refractory to radioactive iodine (RAIR) therapy. Subjects and methods: We reviewed the records of all patients with MKI-treated DTC from 2010 to 2018. Progression free survival (PFS), response rates (RR) and adverse events (AE) profiles...
Pregnancy has no significant impact on the prognosis of differentiated thyroid ...
Nobre,Gabriela Maia; Tramontin,Mariana Yoshii; Treistman,Natalia; Alves Junior,Paulo Alonso; Andrade,Fernanda Accioly; Bulzico,Daniel AlvesABSTRACT Objective: To evaluate the impact of pregnancy on differentiated thyroid carcinomas (DTC) behavior Subjects and methods: Retrospective study of patients diagnosed with DTC before or during pregnancy and treated with standard therapy. In women diagnosed with DTC before pregnancy, we evaluated the occurrence of progression according to categories of response to therapy based on imaging and non-stimulated...
Cholestatic syndrome as initial manifestation of pancreatic metastasis of papil...
Tramontin,Mariana Yoshii; Faria,Paulo Antônio Silvestre de; Nascimento,Cristina Moreira do; Barbosa,Cibele de Aquino; Barros,Maria de Fátima Rei PereiraSUMMARY Most papillary thyroid carcinomas (PTC) harbor excellent prognosis. Although rare, distant metastases normally occur in lungs and/or bones. Here we describe a rare case of pancreatic metastasis presenting with rapid onset cholestatic syndrome. A literature review was also performed. A 73-year-old man with a high risk PTC was submitted to total thyroidectomy (TT) followed by radioiodine therapy. After in...
Serum calcitonin nadirs to undetectable levels within 1 month of curative surge...
Andrade,Fernanda; Rondeau,Geneviève; Boucai,Laura; Zeuren,Rebecca; Shaha,Ashok R.; Ganly,Ian; Vaisman,Fernanda; Corbo,Rossana; Tuttle,MichaelABSTRACT Objective: Because serum calcitonin (CT) is a reliable marker of the presence, volume, and extent of disease in medullary thyroid cancer (MTC), both the ATA and NCCN guidelines use the 2-3 month post-operative CT value as the primary response to therapy variable that determines the type and intensity of follow up evaluations. We hypothesized that the calcitonin would nadir to undetectable levels within...
Clinical outcomes of low and intermediate risk differentiated thyroid cancer pa...
Súss,Shirlei Kugler Aiçar; Mesa Jr.,Cleo Otaviano; Carvalho,Gisah Amaral de; Miasaki,Fabíola Yukiko; Chaves,Carolina Perez; Fuser,Dominique CochatABSTRACT Objective To retrospectively evaluate the outcomes of patients with low and intermediate risk thyroid carcinoma treated with total thyroidectomy (TT) and who did not undergo radioiodine remnant ablation (RRA) and to compare them to patients receiving low dose of iodine (30 mCi). Subjects and methods A total of 189 differentiated thyroid cancer (DTC) patients treated with TT followed by 30mCi for RRA or...
Metastatic lymph node characteristics as predictors of recurrence/persistence i...
Barbosa,Mayara Peres; Momesso,Denise; Bulzico,Daniel Alves; Farias,Terence; Dias,Fernando; Lima,Roberto Araújo; Corbo,Rossana; Vaisman,MarioABSTRACT Objective: The aim of this study was to evaluate the association between this characteristic and outcomes in patients with lymph node metastasis in a Brazilian cohort. Subjects and methods: This study examined a retrospective cohort of adult patients diagnosed with differentiated thyroid cancer and lymph node metastases from 1998 to 2015 in two referral centers. Number, location, size and extranodal ex...
Is radioactive iodine- 131 treatment related to the occurrence of non-synchrono...
Souza,Marcelo Cruzick de; Momesso,Denise P.; Vaisman,Fernanda; Vieira Neto,Leonardo; Martins,Rosangela Aparecida Gomes; Corbo,Rossana; Vaisman,MarioObjective Much controversy relates to the risk of non-synchronous second primary malignancies (NSSPM) after radioactive iodine treatment (RAI-131) in differentiated thyroid cancer (DTC) patients. This study evaluated the relationship between RAI-131 and NSSPM in DTC survivors with long-term follow-up. Materials and methods Retrospective analysis of 413 DTC cases was performed; 252 received RAI-131 and 161 were ...
Análise dosimétrica de acompanhantes de pacientes de medicina nuclear internado...
Oliveira,Jetro Pereira de; Lopes,Márcia Maria dos Santos; Rosa,Luiz Antonio Ribeiro da; Fonseca,Léa Mirian Barbosa da; Corbo,RossanaOBJETIVO: Este trabalho avaliou doses recebidas por acompanhantes que compartilharam o mesmo quarto terapêutico com pacientes tratados com câncer de tireóide ingerindo iodo-131 (131I) e comparou os resultados obtidos aos limites determinados pelas normas brasileiras de radioproteção. MATERIAIS E MÉTODOS: Avaliaram-se seis grupos de pessoas. Cada grupo foi formado por um acompanhante e um paciente, que compartil...
Efeitos da radioiodoterapia nas gerações futuras de mulheres com carcinoma dife...
Brandão,Carmen Dolores Gonçalves; Antonucci,Jane; Correa,Nilson Duarte; Corbo,Rossana; Vaisman,MarioA radioiodoterapia tem conseguido desempenhar um papel significante no tratamento do carcinoma diferenciado de tireóide. A literatura é limitada em relação a possíveis efeitos secundários do 131I, embora o interesse tenha aumentado nesse campo. A importância de se saber mais sobre os efeitos mutagênicos da radiação em filhos de mães expostas ao 131I para tratamento do carcinoma diferenciado de tireóide é devida...