12 documents found, page 1 of 2
Synthesis, characterization and biological activity of methotrexate-derived sal...
Silva, Dário; Cordeiro, Sandra; Baptista, Pedro V.; Fernandes, Alexandra R.; Branco, Luis C.We acknowledge Dra Catarina Rodrigues for technical support in MTS assays. Publisher Copyright: © 2025 RSC.; Lung cancer is one of the deadliest types of cancer, and is a public health problem worldwide. Methotrexate (MTX), a class IV drug in the biopharmaceutical classification system, is a folate antagonist that has demonstrated efficacy in cancer treatment. A suitable combination of MTX as a di-anion and bio...
Copper(II) Complexes with 2,2′:6′,2″-Terpyridine Derivatives Displaying Dimeric...
Choroba, Katarzyna; Machura, Barbara; Erfurt, Karol; Casimiro, Ana Rita; Cordeiro, Sandra; Baptista, Pedro V.; Fernandes, Alexandra R.This work was cofinanced by national funds from FCT-Fundação para a Ciência e a Tecnologia, I.P., in the scope of the project UIDP/04378/2020 (doi: 10.54499/UIDP/04378/2020) and UIDB/04378/2020 (doi: 10.54499/UIDB/04378/2020) of the Research Unit on Applied Molecular Biosciences-UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy-i4HB and doctoral grant 2021.086...
Exploiting Co(III)-Cyclopentadienyl Complexes To Develop Anticancer Agents
Franco Machado, João; Cordeiro, Sandra; Duarte, Joana N.; Costa, Paulo J.; Mendes, Paulo J.; Garcia, Maria Helena; Baptista, Pedro V.Publisher Copyright: © 2024 The Authors. Published by American Chemical Society.; In recent years, organometallic complexes have attracted much attention as anticancer therapeutics aiming at overcoming the limitations of platinum drugs that are currently marketed. Still, the development of half-sandwich organometallic cobalt complexes remains scarcely explored. Four new cobalt(III)-cyclopentadienyl complexes co...
Breaking the mold
Cordeiro, Sandra; Oliveira, Beatriz B.; Valente, Ruben; Ferreira, Daniela; Luz, André; Baptista, Pedro V.; Fernandes, Alexandra R.Publisher Copyright: Copyright © 2024 Cordeiro, Oliveira, Valente, Ferreira, Luz, Baptista and Fernandes.; Despite extensive efforts to unravel tumor behavior and develop anticancer therapies, most treatments fail when advanced to clinical trials. The main challenge in cancer research has been the absence of predictive cancer models, accurately mimicking the tumoral processes and response to treatments. The tum...
Effect of mono- and dinuclear thiosemicarbazone platinacycles in the proliferat...
Reigosa-Chamorro, Francisco; Cordeiro, Sandra; Pereira, M. Teresa; Filipe, Beatriz; Baptista, Pedro V.; Fernandes, Alexandra R.; Vila, José M.This work was also made possible thanks to the financial support received from the Xunta de Galicia (Galicia, Spain) under the Grupos de Referencia Competitiva Programme (project GRC2019/14). F. R. thanks the Spanish Ministry of Education (grant FPU15/07145). Publisher Copyright: © 2024 The Royal Society of Chemistry.; Herein, we describe the synthesis and characterization of a series of thiosemicarbazone plati...
Optimization of Antiproliferative Properties of Triimine Copper(II) Complexes
Choroba, Katarzyna; Zowiślok, Bartosz; Kula, Sławomir; Machura, Barbara; Maroń, Anna M.; Erfurt, Karol; Marques, Cristiana; Cordeiro, SandraThis research was funded by the National Science Centre of Poland, SONATA grant no. 2020/39/D/ST4/00286 (A.M.M.). The research activities were cofinanced by the funds granted under the Research Excellence Initiative of the University of Silesia in Katowice. Publisher Copyright: © 2024 The Authors. Published by American Chemical Society.; Cu(II) complexes with 2,2′:6′,2″-terpyridines (terpy) and 2,6-bis(thiazol-...
In Vitro and In Vivo Biological Activities of Dipicolinate Oxovanadium(IV) Comp...
Choroba, Katarzyna; Filipe, Beatriz; Świtlicka, Anna; Penkala, Mateusz; Machura, Barbara; Bieńko, Alina; Cordeiro, Sandra; Baptista, Pedro V.funds granted under the Research Excellence Initiative of the University of Silesia in Katowice. The authors thank Dr inż. Mariola Siwy for measurements of elemental analysis. Publisher Copyright: © 2023 The Authors. Published by American Chemical Society.; The work is focused on anticancer properties of dipicolinate (dipic)-based vanadium(IV) complexes [VO(dipic)(N∩N)] bearing different diimines (2-(1H-imidazo...
Doxorubicin-sensitive and -resistant colorectal cancer spheroid models
Valente, Ruben; Cordeiro, Sandra; Luz, André; Rodrigues, Catarina Roma; Baptista, Pedro V.; Fernandes, Alexandra R.The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was financed by national funds from FCT–Fundação para a Ciência e a Tecnologia, I.P./MCTES through the projects PTDC/QUIQIN/0146/2020. Publisher Copyright: Copyright © 2023 Valente, Cordeiro, Luz, Melo, Rodrigues, Baptista and Fernandes.; Introduction: The research on tumor microenvir...
Doxorubicin-sensitive and -resistant colorectal cancer spheroid models
Valente, Ruben; Cordeiro, Sandra; Luz, André; Rodrigues, Catarina Roma; Baptista, Pedro V.; Fernandes, Alexandra R.The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was financed by national funds from FCT–Fundação para a Ciência e a Tecnologia, I.P./MCTES through the projects PTDC/QUIQIN/0146/2020. Publisher Copyright: Copyright © 2023 Valente, Cordeiro, Luz, Melo, Rodrigues, Baptista and Fernandes.; Introduction: The research on tumor microenvir...
Evaluation of the in vitro and in vivo efficacy of ruthenium polypyridyl compou...
Lenis‐Rojas, Oscar A.; Roma‐Rodrigues, Catarina; Fernandes, Alexandra R.; Carvalho, Andreia; Cordeiro, Sandra; Guerra‐Varela, Jorge; Sánchez, LauraProject ED431C 2018/39 PEst 20152020 UID/QUI/00100/2020 UIDP/04378/2020 UIDB/04378/2020 LA/P/0140/2020; The clinical success of cisplatin, carboplatin, and oxaliplatin has sparked the interest of medicinal inorganic chemistry to synthesize and study compounds with non‐platinum metal centers. Despite Ru(II)–polypyridyl complexes being widely studied and well established for their antitumor properties, there are ...