5 documents found, page 1 of 1
Pharmacogenetics of advanced lung cancer: Predictive value of functional geneti...
Catarata, MJ; Lourenço, M; Martins, MF; Frade, J; Pêgo, A; Cordeiro, CR; Medeiros, R; Ribeiro, RIntroduction: AGXT gene codes for the enzyme alanine glyoxylate aminotransferase, which is involved in hepatic peroxisomal metabolism of platinum-based chemotherapeutic agents. The association of genetic variant AGXT rs34116584 on the clinical outcome and response to chemotherapy of patients with non-small cell lung cancer (NSCLC) remains to be established. Our aim was to evaluate the association of functional ...
Alpha-1 Antitrypsin Deficiency: Principles of Care
Rodrigues, JF; Mineiro, A; Reis, A; Ventura, DG; Fernandez Llimos, F; Costa, F; Gomes, J; Silva, JM; Lopes, P; Cordeiro, CRAlpha-1 antitrypsin deficiency is an autosomal co-dominant inherited disorder that results in decreased circulating levels of alpha-1 antitrypsin (also known as alpha-1 proteinase inhibitor) and predisposes affected individuals to early onset lung and liver disease. There is currently no cure for alpha-1 antitrypsin deficiency. However, appropriate treatment and a high standard of clinical care can prevent pati...
Germline genetic variants of the renin-angiotensin system, hypoxia and angiogen...
Catarata, MJ; Medeiros, R; Oliveira, MJ; Pêgo, A; Frade, JG; Martins, MF; Cordeiro, CR; Herth, FJF; Thomas, M; Kriegsmann, M; Meister, M; Schneider, MAIntroduction: The renin–angiotensin system (RAS) is involved in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. Our aim was to study the association of putatively functional genetic polymorphisms in genes coding for proteins involved in RAS, hypoxia and angiogenesis with non-small cell lung cancer (NSCLC) prognosis. Methods: Geno...
Renin-angiotensin system in lung tumor and microenvironment interactions
Catarata, MJ; Ribeiro, R; Oliveira, MJ; Cordeiro, CR; Medeiros, RThe mechanistic involvement of the renin-angiotensin system (RAS) reaches beyond cardiovascular physiopathology. Recent knowledge pinpoints a pleiotropic role for this system, particularly in the lung, and mainly through locally regulated alternative molecules and secondary pathways. Angiotensin peptides play a role in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical...
Strengthening tuberculosis control to advance towards elimination: The 2018 Rev...
Duarte, R; Migliori, GB; Zumla, A; Cordeiro, CRn/a