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Evaluation of urinary cysteinyl leukotrienes as biomarkers of severity and puta...

Reina-Couto, M; Roboredo-Madeira, M; Pereira-Terra, P; Silva-Pereira, C; Martins, S; Teixeira-Santos, L; Pinho, D; Dias, A; Cordeiro, G; Dias, CC

Background Cysteinyl leukotrienes (CysLT) are potent inflammation-promoting mediators, but remain scarcely explored in COVID-19. We evaluated urinary CysLT (U-CysLT) relationship with disease severity and their usefulness for prognostication in hospitalized COVID-19 patients. The impact on U-CysLT of veno-venous extracorporeal membrane oxygenation (VV-ECMO) and of comorbidities such as hypertension and obesity ...


Aphasia Rapid Test: Translation, Adaptation and Validation Studies for the Port...

Tábuas-Pereira, M; Freitas, S; Beato-Coelho, J; Ribeiro, JA; Parra, J; Martins, C; Silva, M; Matos, MA; Nogueira, AR; Silva, F; Sargento-Freitas, J

Classical aphasia evaluation scales are too long to use in the context of acute stroke or as a monitoring tool. The Aphasia Rapid Test is a 26-point scale developed as a bedside assessment to rate aphasia severity in acute stroke patients in less than 3 minutes. We aimed to adapt and validate this scale for European Portuguese.


Nocturnal Blood Pressure Dipping in Acute Ischemic Stroke

Sargento-Freitas, J; Laranjinha, I; Galego, O; Rebelo-Ferreira, A; Moura, B; Correia, M; Silva, F; Machado, C; Cordeiro, G; Cunha, L

OBJECTIVES: We aim to assess the impact of early nocturnal blood pressure (BP) variation in the functional outcome of patients after an acute ischemic stroke. MATERIALS AND METHODS: We included consecutive stroke patients treated with intravenous thrombolysis (IVrtPA) in a tertiary stroke center. BP measurements were performed at regular intervals throughout day and night during the first 48 h after stroke onse...


Recurrence in intracranial atherosclerotic disease: a stenosis-based analysis

Gouveia, A; Sargento-Freitas, J; Penetra, J; Silva, F; Machado, C; Cordeiro, G; Cunha, L

BACKGROUND: Intracranial atherosclerotic disease is a common cause of stroke; its incidence and prevalence vary widely by ethnicity. The aim of our study was to analyze the recurrence rate of cerebrovascular events in patients with symptomatic and asymptomatic intracranial stenosis (IS). METHODS: We conducted a historical cohort study including all patients admitted in our hospital for stroke or transient ische...


[Carotid atherosclerosis and white matter hypodensities: a controversial relati...

Félix-Morais, R; Sargento-Freitas, J; Silva, F; Cordeiro, G; Nunes, C; Ribeiro, J; Cordeiro, M; Moura, C; Cunha, L

INTRODUCTION: White matter hypodensities of presumed vascular origin, are recognized as an important cause of morbidity with established clinical and cognitive consequences. Nonetheless, many doubts remain on its physiopathology. Our goal is to clarify the potential role of carotid atherosclerosis and other vascular risk factors in the development of white matter hypodensities of presumed vascular origin. MATER...


Craniectomia descompressiva na enfarte cerebral maligno

Cabrita, F; Pereira, R; Carvalho, M; Cordeiro, G; Barbosa, MD


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