6 documents found, page 1 of 1
Early Outcomes of Brolucizumab Switch in Wet Age- Related Macular Degeneration:...
Correia, Marta; Baptista, Margarida; Cordeiro, Miguel; Picoto, Maria; Vaz, FernandaINTRODUCTION: Age-related macular degeneration (AMD) is the leading cause of blindness in the developed world. The use of anti-vascular endothelial growth factor (VEGF) revolu- tionized the treatment of neovascular AMD (nAMD) despite being a known burden to both patients and healthcare systems. Brolucizumab is a newer anti-VEGF agent, whose noninferiority to aflibercept in visual outcomes in treatment-naïve eye...
Design and development of a web-based prospective nationwide registry for ocula...
Leal, Ines; Nogueira, Vanda; Matos, Diogo Bernardo; Araújo, Joana; Berens, Olga; Ribeiro, Margarida; Furtado, Maria João; Liverani, MarcoUveitis is a heterogeneous collection of infrequent diseases, which poses significant challenges to cost-effective research in the field. Medical registries are being increasingly recognized as crucial tools to provide high-quality data, thus enabling prospective clinical research. This paper describes the design and technical structure development of an innovative countrywide electronic medical record for uvei...
Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome
Arede, Pedro Bruno; Cordeiro, Miguel; Guedes, MartaTubulointerstitial Nephritis and Uveitis (TINU) syndrome is characterized by bilateral anterior uveitis and idiopathic tubulointerstitial nephritis. A 37-year-old female with bilateral anterior uveitis, malaise and fever was evaluated at the Ophthalmology Emergency department. Laboratory investigation revealed an elevated C-re- active protein, a raised erythrocyte sedimentation ratio and a sub-nephrotic protein...
Aterosclerose Carotídea e Hipodensidades da Substância Branca: uma Relação Cont...
Félix-Morais, Ricardo; Sargento-Freitas, João; Silva, Fernando; Cordeiro, Gustavo; Nunes, César; Ribeiro, Joana; Cordeiro, Miguel; Moura, CristinaIntrodução: As hipodensidades da substância branca de provável etiologia vascular, são uma causa importante de morbilidade, condicionando deterioração cognitiva. No entanto, numerosas dúvidas persistem quanto à sua fisiopatologia. O objectivo deste estudo é clarificar o papel da aterosclerose carotídea e outros factores de risco vascular no desenvolvimento das hipodensidades da substância branca de provável eti...
Carotid Atherosclerosis and White Matter Hypodensities: a Controversial Relatio...
Félix-Morais, Ricardo; Sargento-Freitas, João; Silva, Fernando; Cordeiro, Gustavo; Nunes, César; Ribeiro, Joana; Cordeiro, Miguel; Moura, CristinaIntroduction: White matter hypodensities of presumed vascular origin, are recognized as an important cause of morbidity with established clinical and cognitive consequences. Nonetheless, many doubts remain on its physiopathology. Our goal is to clarify the potential role of carotid atherosclerosis and other vascular risk factors in the development of white matter hypodensities of presumed vascular origin.Materi...
Conventional and Diffusion-weighted Magnetic Resonance Imaging and Proton Spect...
Casimiro, Carlos; Martins, Joana; Nunes, César; Parreira, Tiago; Batista, Sónia; Cordeiro, Miguel; Matias, Fernando; Rebelo, Olinda; Freitas, PedroIntroduction: MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes) is a mitochondrial hereditary dysfunction in which the physiopathological mechanism of cerebral lesions is not totally understood as yet. Typically, these lesions are described as having normal to increased apparent diffusion coefficient (ADC), and this has been used to distinguish stroke-like lesions from ischemic ...