43 documents found, page 1 of 5

Surtos de mpox em Portugal: resposta laboratorial e desafios no controlo da epi...

A infeção mpox, causada pelo vírus monkeypox (MPXV), tornou-se uma emergência global de saúde pública em 2022. Portugal foi um dos primeiros países a confirmar casos de infeção, o que levou à implementação de um sistema de vigilância laboratorial a nível nacional. Este estudo descreve a evolução epidemiológica de mpox em Portugal entre 2022 e 2025 e avalia o desempenho de diferentes tipos de amostras biológicas...

Probe-based metagenomic pathogen detection: advancing laboratory capacity for c...

Probe-based pathogen enrichment, followed by NGS, is a promising tool for complex diagnosis, overcoming traditional challenges of shotgun metagenomics, namely small microbial/human genetic material ratio and demanding computational resources. Here, we assessed the combined detection performance of two Illumina probe-based panels, the Respiratory and the Urinary Pathogen ID panels (RPIP and UPIP), using 99 clini...

European pilot interlaboratory comparison study on Mpox virus whole genome sequ...

Objectives: Since 2022, distinct Mpox virus (MPXV) clades have been spreading across different geographic regions, causing a challenging epidemiological situation. Whole genome sequencing (WGS) proved to be instrumental for patient management and global public health. We report a pilot interlaboratory comparison study for MPXV WGS. Methods: We distributed noninfectious DNA samples, including the main MPXV clade...

Viral genetics and transmission dynamics in the second wave of mpox outbreak in...

An Overview of Monkeypox Virus Detection in Different Clinical Samples and Anal...

Mpox is a zoonotic disease caused by the Monkeypox virus (MPXV), and since May 2022, tens of thousands of cases have been reported in non-endemic countries. We aimed to evaluate the suitability of different sample types for mpox diagnostic and assess the temporal dynamics of viral load. We evaluated 1914 samples from 953 laboratory-confirmed cases. The positivity rate was higher for lesion (91.3%) and rectal sw...

Use and management of Trastuzumab Deruxtecan in people with breast cancer: reco...

Trastuzumab Deruxtecan is indicated for the treatment of Human Epidermal growth factor Receptor-type 2 HER2-positive or HER2-low breast cancer, showing favorable efficacy and safety profiles. However, it can lead to some severe adverse events, such as interstitial lung disease. We performed four regional experience sharing sessions and one final national discussion session, with the participation of several nur...

O efeito da Responsabilidade Social Corporativa (RSC) na construção da imagem d...

Neste artigo é investigado o papel da Responsabilidade Social Corporativa (RSC) na construção da imagem de marca, utilizando a Disney como caso de estudo. Foi adotada uma abordagem mista, combinando métodos qualitativos e quantitativos. No método qualitativo, foram analisados e comparados dois relatórios corporativos da The Walt Disney Company, datados de 2008 e 2022. No método quantitativo, foi aplicado um que...

Afinal, quem descobriu o ADN?

O ADN, ou ácido desoxirribonucleico, é a molécula que armazena toda a informação genética de um organismo e está presente em todos os organismos conhecidos, tais como o ser humano, uma árvore ou uma bactéria. A designação de ácido desoxirribonucleico vem da sua natureza ácida (“ácido”) e do nome dos seus componentes, os hidratos de carbono (“desoxirribo-” de desoxirribose) e os nucleótidos (“- nucleico”).

Metabolomic and taxonomic characterization of Haloleptolyngbya lusitanica sp. n...

The morphological plasticity of cyanobacteria and their widespread ecological dominance in a wide range of habitats highlights the need for in-depth taxonomic studies. This work focused on the taxonomical revision of Leptolyngbya (Cyanophyceae) strains deposited in the ESSACC culture collection and their metabolomic characterization. Although the studied ESSACC strains were morphologically identified as Leptoly...

Demographic and Clinical Characteristics of Mpox Patients Attending an STD Clin...

Mpox is a viral disease caused by the monkeypox virus, which marked the year of 2022 with a global outbreak. While previously considered to be a zoonosis of almost exclusive animal-to-human transmission, the current outbreak has been attributed to human-to-human transmission, particularly sexual transmission. As a new sexually transmissible disease, we studied the epidemiological and clinical features, as well ...