6 documents found, page 1 of 1
Successful Deceased Donor Kidney Transplantation in a Highly Sensitized Patient...
Alferes,Daniela; Tafulo,Sandra; Tavares,Isabel; Nunes,Ana Teresa; Rocha,Ana; Bustorff,Manuela; Sampaio,SusanaABSTRACT For patients with end stage renal disease, kidney transplant offers significant survival and quality-of-life advantages compared with dialysis. But for patients seeking transplant who are highly sensitized, waiting times have traditionally been long and options limited. We present the case of a 34-year-old hypersensitized female who underwent renal retransplantation. Histocompatibility tests revealed a...
A case of lupus podocytopathy and a review of the literature
Silvano,José; Praça,Augusta; Ferreira,Inês Castro; Nunes,Ana Teresa; Rodrigues-Pereira,Pedro; Silva,Roberto Pestana; Sampaio,Susana; Pestana,ManuelABSTRACT Nephrotic syndrome in systemic lupus erythematosus patients with histological evidence of minimal change disease, mesangial proliferation or focal and segmental glomerulosclerosis on light microscopy, represents a distinct clinical entity - lupus podocytopathy. This entity is characterized by a diffuse foot process effacement on electron microscopy and by absence of subepithelial or subendothelial immu...
Anti-phospholipase A2 receptor antibodies: Current applications in primary memb...
Relvas,Miguel; Batata,Rodrigo; Nunes,Ana Teresa; Coentrão,LuísBackground: Membranous nephropathy (MN) is among the most common causes of nephrotic syndrome in nondiabetic adults. The podocytic M-type phospholipase A2 receptor (PLA2R) has been identified as the major antigenic target of the immune response that underlies primary membranous nephropathy (PMN). In the last decade, anti-PLA2R antibodies have been seen as promising diagnostic biomarkers for PMN. Other potential...
Cancer screening in membranous nephropathy: How deep should we go? - A case rep...
Mendonça,Luís; Silva,Roberto; Nunes,Ana TeresaMembranous nephropathy is the most common cause of nephrotic syndrome in white adults. A non-negligible number of cases are associated with systemic conditions, namely cancer. We report the case of a 70-year-old man who presented with nephrotic syndrome and was diagnosed with membranous nephropathy. Although the initial screening did not detect any neoplastic lesion, additional exams revealed a nasopharyngeal c...
New treatments in membranous glomerulopathy - from the pitfalls of rituximab to...
Ferreira,Filipa; Nunes,Ana TeresaPrimary membranous nephropathy (PMN) is the main cause of nephrotic syndrome in adults. The recognition that this kidney-specific disease is the result of an autoimmune process has changed diagnostic and therapeutic approaches. The determination of anti-phospholipase A2 receptor and thrombospondin type-1 domain containing 7A, when available, are part of the diagnostic and therapeutic monitoring workup. More rec...
Gravidez na doença renal crónica: da diálise peritoneal à hemodiálise
Pinto,Pedro Viana; Nunes,Ana Teresa; Santos,Carla; Martins,Patricia; Machado,Ana Paula; Montenegro,NunoOverview and Aims: pregnancy in women with chronic kidney disease (CKD), particularly in terminal CKD, remains a rare event. There are scarce reports of pregnancy in women undergoing peritoneal dialysis. Our study aims to evaluate the outcomes of pregnancies in women with CKD diagnosed at Hospital São João during the study period. Study design: retrospective case series. Population: pregnant women with chronic ...