7 documents found, page 1 of 1
Global guideline for the diagnosis and management of candidiasis: an initiative...
Cornely, Oliver A.; Sprute, Rosanne; Bassetti, Matteo; Chen, Sharon C-A; Groll, Andreas H.; Kurzai, Oliver; Lass-Flörl, CorneliaCandida species are the predominant cause of fungal infections in patients treated in hospital, contributing substantially to morbidity and mortality. Candidaemia and other forms of invasive candidiasis primarily affect patients who are immunocompromised or critically ill. In contrast, mucocutaneous forms of candidiasis, such as oral thrush and vulvovaginal candidiasis, can occur in otherwise healthy individual...
Multicentric Study on the Clinical Mycology Capacity and Access to Antifungal T...
Fernandes, Raquel; Sabino, Raquel; Cunha, Cristina; Cornely, Oliver A.; Carvalho, Agostinho; Salmanton‑García, JonThe success of the clinical management of invasive fungal diseases (IFD) is highly dependent on suitable tools for timely and accurate diagnosis for effective treatment. An in-depth analysis of the ability of European institutions to promptly and accurately diagnose IFD was previously conducted to identify limitations and aspects to improve. Here, we evaluated and discussed the specific case of Portugal, for wh...
Risk Factors for Primary Clostridium difficile Infection; Results From the Obse...
Davies, Kerrie; Lawrence, Jody; Berry, Claire; Davis, Georgina; Yu, Holly; Cai, Bing; Gonzalez, Elisa; Prantner, Ida; Kurcz, Andrea; Macovei, IoanaBackground: There are inconsistent data on the risk factors for Clostridium difficile infection (CDI) in the literature. Aims: To use two C. difficile infection (CDI) case-control study groups to compare risk factors in hospitalized patients with diarrhea across different countries. Methods: A multi-center group of CDI cases/controls were identified by standardized testing from seven countries from the prior EU...
Invasive pulmonary aspergillosis treatment duration in haematology patients in ...
Lanternier, Fanny; Seidel, Danila; Pagano, Livio; Styczynski, Jan; Mikulska, Malgorzata; Pulcini, Celine; Maertens, Johan; Munoz, PatriciaInvasive pulmonary aspergillosis (IPA) optimal duration of antifungal treatment is not known. In a joint effort, four international scientific societies/groups performed a survey to capture current practices in European haematology centres regarding management of IPA. We conducted a cross-sectional internet-based questionnaire survey in 2017 to assess practices in sixteen European countries concerning IPA manag...
COVID-19 Associated Pulmonary Aspergillosis (CAPA)—From immunology to treatment
Arastehfar, Amir; Carvalho, Agostinho; van de Veerdonk, Frank L.; Jenks, Jeffrey D.; Koehler, Philipp; Krause, Robert; Cornely, Oliver A.Like severe influenza, coronavirus disease-19 (COVID-19) resulting in acute respiratory distress syndrome (ARDS) has emerged as an important disease that predisposes patients to secondary pulmonary aspergillosis, with 35 cases of COVID-19 associated pulmonary aspergillosis (CAPA) published until June 2020. The release of danger-associated molecular patterns during severe COVID-19 results in both pulmonary epith...
ECMM CandiReg - A ready to use platform for outbreaks and epidemiological studies
Koehler, Philipp; Arendrup, Maiken Cavling; Arikan‐Akdagli, Sevtap; Bassetti, Matteo; Bretagne, Stéphane; Klingspor, Lena; Lagrou, KatrienBackground: Recent outbreaks of Candida auris further exemplify that invasive Candida infections are a substantial threat to patients and healthcare systems. Even short treatment delays are associated with higher mortality rates. Epidemiological shifts towards more resistant Candida spp. require careful surveillance. Objectives: Triggered by the emergence of C auris and by increasing antifungal resistance rates...
Azole-Resistance in Aspergillus terreus and Related Species: An Emerging Proble...
Zoran, Tamara; Sartori, Bettina; Sappl, Laura; Aigner, Maria; Sánchez-Reus, Ferran; Rezusta, Antonio; Chowdhary, Anuradha; Taj-Aldeen, Saad J.Objectives: Invasive mold infections associated with Aspergillus species are a significant cause of mortality in immunocompromised patients. The most frequently occurring aetiological pathogens are members of the Aspergillus section Fumigati followed by members of the section Terrei. The frequency of Aspergillus terreus and related (cryptic) species in clinical specimens, as well as the percentage of azole-resi...