4 documents found, page 1 of 1
Systematic Review and Meta-Analysis of Mass Spectrometry Proteomics Applied to ...
Rodrigues, João E.; Martinho, Ana; Santa, Cátia; Madeira, Nuno; Coroa, Manuel; Santos, Vítor; Martins, Maria J.; Pato, Carlos N.; Macedo, AntónioMass spectrometry (MS)-based techniques can be a powerful tool to identify neuropsychiatric disorder biomarkers, improving prediction and diagnosis ability. Here, we evaluate the efficacy of MS proteomics applied to human peripheral fluids of schizophrenia (SCZ) patients to identify disease biomarkers and relevant networks of biological pathways. Following PRISMA guidelines, a search was performed for studies t...
Risk Calculators in Bipolar Disorder: A Systematic Review
Ribeiro, Joana Silva; Pereira, Daniela; Salagre, Estela; Coroa, Manuel; Santos Oliveira, Pedro; Santos, Vítor; Madeira, Nuno; Grande, IriaIntroduction: Early recognition of bipolar disorder improves the prognosis and decreases the burden of the disease. However, there is a significant delay in diagnosis. Multiple risk factors for bipolar disorder have been identified and a population at high-risk for the disorder has been more precisely defined. These advances have allowed the development of risk calculators to predict individual risk of conversi...
The quest for biomarkers in Schizophrenia: from neuroimaging to machine learning
Bajouco, Miguel; Mota, David; Coroa, Manuel; Caldeira, Salomé; Santos, Vítor; Madeira, NunoSchizophrenia is a severe mental disorder and one of the leading causes of disease burden worldwide. It represents a source of signi cant su ering and disability to the a ected individuals, and is associated with substantial societal and economical costs. The diagnosis of schizophrenia still depends exclusively on the detection of symptoms that are also present in other mental disorders. This situation causes o...
Neural connectivity in youth at-risk for bipolar disorder: a review of function...
Santos, Vítor; Coroa, Manuel; Caldeira, Salomé; Bajouco, Miguel; Madeira, NunoBackground: Delayed diagnosis of bipolar disorder (BD) is common in adolescents and young adults and the search for biomarkers to help in early diagnosis in BD at-risk populations is an important goal of neuroimaging research. Functional connectivity studies in BD patients suggests that anomalous connectivity between prefrontal and limbic regions could be risk biomarkers for BD. The aim of this review is to pro...