16 documents found, page 1 of 2
cis-bis(N-benzoyl-N0 ,N0 -dibenzylthioureido) platinum(II) : synthesis, molecul...
Correa, Rodrigo de Souza; Oliveira, Katia Mara de; Pérez, Hiram; Stevens, Ana María Plutín; Cairo, Raúl Ramos; Mocelo, Raúl; Castellano, Eduardo ErnestoIn this paper, the title compound was synthesized from N-benzoyl-N′,N′-dibenzylthiourea ligand and potassium tetrachloroplatinate(II), and its interaction with human (HSA) and bovine (BSA) serum albumin was evaluated. Also, the crystal structure was determined from single-crystal X‐ray diffraction, confirming that the platinum atom is coordinated with two chelated N-benzoyl-N′,N′-dibenzylthiourea ligands in a d...
Ru(II)-thymine complex causes DNA damage and apoptotic cell death in human colo...
Silva, Suellen Laila Rocha; Baliza, Ingrid R. S.; Dias, Rosane Borges; Sales, Caroline Brandi Schlaepfer; Rocha, Clarissa Araújo GurgelRu(II)-thymine complex [Ru(PPh3)2(Thy)(bipy)]PF6 (where PPh3 = triphenylphosphine, Thy = thyminate and bipy = 2,2′-bipyridine) is a potent cytotoxic agent with ability to bind to DNA, inducing caspase-mediated apoptosis in leukemia cells. In this study, we investigated the mechanism underlying the cell death induction by Ru(II)-thymine complex in human colon carcinoma HCT116 cells, as well as its effect in xeno...
Ruthenium(II) complexes with 6-methyl-2-thiouracil selectively reduce cell prol...
Bomfim, Larissa Mendes; Araujo, Fênix Alexandra de; Dias, Rosane Borges; Sales, Caroline Brandi Schlaepfer; Rocha, Clarissa Araújo GurgelRuthenium(II) complexes with 6-methyl-2-thiouracil cis-[Ru(6m2tu)2(PPh3)2] (1) and [Ru(6m2tu)2(dppb)] (2) (where PPh3 = triphenylphosphine; dppb = 1,4-bis(diphenylphosphino)butane; and 6m2tu = 6-methyl-2-thiouracil) are potent cytotoxic agents and able to bind DNA. The aim of this study was to evaluate in vitro cellular underlying mechanism and in vivo effectiveness of these ruthenium(II) complexes in human acu...
Nucleobase derivatives as building blocks to borm Ru(II)-based complexes with h...
Carvalho, Diogo Émerson Leite de; Oliveira, Katia Mara de; Bomfim, Larissa Mendes; Soares, Milena Botelho Pereira; Bezerra, Daniel PereiraTwo new Ru(II)-based complexes containing 2-thiouracil derivatives, known as 2-thiouracil (2TU) and 6-methyl-2-thiouracil (6m2TU), were synthesized using cis,trans-[RuCl2(PPh3)2(bipy)] as a precursor. The obtained compounds with a general formula trans-[Ru(2TU)(PPh3)2(bipy)]PF6 (1) and trans-[Ru(6m2TU)(PPh3)2(bipy)]PF6 (2) were characterized by analytical techniques such as NMR, UV–vis, and IR spectroscopies, e...
Ru(II)-thymine complex causes cell growth inhibition and induction of caspase-m...
Oliveira, Maiara de Souza; Santana, Adila Angélica Dantas de; Correa, Rodrigo de Souza; Soares, Milena Botelho Pereira; Batista, Alzir AzevedoRuthenium-based compounds represent a class of potential antineoplastic drugs. Recently, we designed, synthesized, and identified the Ru(II)-thymine complex [Ru(PPh3)2(Thy)(bipy)]PF6 (where PPh = triphenylphosphine, Thy = thymine and bipy = 2,2′-bipyridine) as a potent cytotoxic agent with the ability to bind to DNA and human and bovine serum albumins. In this study, the underlying cytotoxic mechanism of the [R...
Polypyridyl ruthenium complexes : novel DNA-intercalating agents against human ...
Reis, João Paulo Barolli; Correa, Rodrigo de Souza; Miranda, Fabio da Silva; Ribeiro, Juliana Uema; Bloch Junior, Carlos; Ellena, Javier AlcidesThis paper describes a new series of four DNA-intercalating agents with promising anticancer activities, based on ruthenium(II) with the planar ligand dpqQX (dpqQX = dipyrido[3,2-a:2',3'-c]quinoxaline[2,3-b]quinoxaline). The complexes identified as trans-[RuCl2(dppb)(dpqQX)], cis-[RuCl2(dppb)(dpqQX)], ct-[RuCl(CO)(dppb)(dpqQX)]PF6 and ct-[RuCl2(PPh3)2(dpqQX)] (dppb = 1,4-bis(diphenylphosphine)butane and PPh3 = ...
Antitumor and anti-Mycobacterium tuberculosis agents based on cationic rutheniu...
Santos, Edjane Rocha dos; Correa, Rodrigo de Souza; Cunha, Lucas Vinícius Pozzi da; Graminha, Angelica Ellen; Araujo, Heloisa Sobreiro Selistre deSix new complexes of Ru(II)/phenanthroline/1,4-bis(diphenylphosphino)butane containing amino acids (Glycine, L-Alanine, L-Valine, L-Tyrosine, L-Methionine or L-Tryptophan) were synthesized and characterized by IR, 31P{1H}, 13C and 1H NMR spectroscopies and cyclic voltammetry experiments. These data suggest the presence of diastereoisomers, except for the complex with glycine, amino acid that does not exhibit ch...
Understanding the conformational changes and molecular structure of furoyl thio...
Cairo, Raúl Ramos; Stevens, Ana María Plutín; Oliveira, Tamires Donizeth de; Batista, Alzir Azevedo; Castellano, Eduardo Ernesto; Duque, Julio1-Acyl thioureas [R1C(O)NHC(S)NR2R3] are shown to display conformational flexibility depending on the degree of substitution at the nitrogen atom. The conformational landscape and structural features for two closely related thioureas having R1=2-furoyl have been studied. The un-substituted 2-furoyl thiourea (I) and its dimethyl analogue, i.e. 1-(2-furoyl)-3,3-dimethyl thiourea (II), have been synthesized and fu...
Reactive nitrogen/oxygen species production by nitro/nitrosyl supramolecular ru...
Barbosa, Marília Imaculada Frazão; Gimenez Parra, Gustavo; Correa, Rodrigo de Souza; Sampaio, Renato Neiva; Magno, Lais Nogueira; Silva, Rodrigo CostaThis manuscript reports on new nitro/nitrosyl Ru-based complexes, which were synthesized with the purpose of using them as precursors to obtain supramolecular ruthenium porphyrin species ({TPyP[Ru (NO2)(5,50-Mebipy)2]4}(PF6)4) and ({TPyP[Ru(NO)(5,50-Mebipy)2]4}(PF6)12). The photochemical and photophysical properties of these porphyrin species were investigated. Results show that the complex containing nitrite i...
A ruthenium-based 5-fluorouracil complex with enhanced cytotoxicity and apoptos...
Silva, Valdenizia Rodrigues; Correa, Rodrigo de Souza; Santos, Luciano de Souza; Soares, Milena Botelho Pereira; Batista, Alzir AzevedoCombination of multifunctionalities into one compound is a rational strategy in medicinal chemical design, and have often been used with metallodrug-based compounds. In the present study, we synthesized a novel ruthenium-based 5-fluorouracil complex [Ru(5-FU)(PPh3)2(bipy)]PF6 (PPh3 = triphenylphosphine; and bipy = 2,2′-bipyridine) with enhanced cytotoxicity in different cancer cells, and assessed its apoptosis ...