4 documents found, page 1 of 1
Serological profile of John Cunningham virus (JCV) in patients with multiple sc...
Branco,Luciana Prats; Adoni,Tarso; Apostolos-Pereira,Samira Luisa; Brooks,Joseph Bruno Bidin; Correa,Eber Castro; Damasceno,Carlos AugustoABSTRACT Treatment options for multiple sclerosis (MS) have changed over the last few years, bringing about a new category of drugs with more efficient profiles. However, these drugs have come with a whole new profile of potential adverse events that neurologists have to learn well and quickly. One of the most feared complications of these MS treatments is progressive multifocal leukoencephalopathy caused by th...
Safety of switching from natalizumab straight into fingolimod in a group of JCV...
Fragoso,Yara Dadalti; Alves-Leon,Soniza Vieira; Becker,Jefferson; Brooks,Joseph Bruno Bidin; Correa,Eber Castro; Damasceno,Alfredo; Gama,Paulo Diniz daABSTRACT Objective To assess safety of the switch between natalizumab and fingolimod without a washout period. Methods Prospective data on 25 JCV positive patients who underwent this medication switch were collected and analyzed. Results After a median period of nine months from the medication switch, there were no safety issues to report. The patients had good disease control and no adverse events were reporte...
Multiple sclerosis in South America: month of birth in different latitudes does...
Fragoso,Yara Dadalti; Adoni,Tarso; Almeida,Sandra Maria Garcia de; Alves-Leon,Soniza Vieira; Arruda,Walter Oleschko; Barbagelata-Aguero,FiorellaObjective To assess whether the month of birth in different latitudes of South America might influence the presence or severity of multiple sclerosis (MS) later in life. Methods Neurologists in four South American countries working at MS units collected data on their patients' month of birth, gender, age, and disease progression. Results Analysis of data from 1207 MS patients and 1207 control subjects did not s...
Multiple sclerosis starting before the age of 18 years: the Brazilian experience
Fragoso,Yara Dadalti; Ferreira,Maria Lucia Brito; Morales,Nivea de Macedo Oliveira; Arruda,Walter Oleschko; Brooks,Joseph Bruno BidinMultiple sclerosis (MS) starting in childhood and adolescence poses a challenge for diagnosis and management of the disease. The aim of the present study was to assess the characteristics of early onset MS in Brazilian patients. Methods Retrospective data collection from specialized MS units. Results From 20 MS units in 11 Brazilian states, 117 cases of MS starting before the age of 18 years were collected. The...