28 documents found, page 1 of 3
Self-assembly pathway influence on Dehydropeptide-based gel properties and drug...
Veloso, Sérgio R S; Vijayakanth, Thangavel; Shankar, Sudha; Fridman, Natalia; Rencus-Lazar, Sigal; Hilliou, L.; Rodrigues, Pedro V.; Moura, C.Low-molecular-weight peptide-based hydrogels formed through self-assembly have emerged as promising candidates for biomedical applications. While the self-assembly process is known to affect the network morphology, its impact on mechanical properties and drug delivery remains poorly understood. In this work, it is explored how different gelation conditions influence the morphology, properties, and drug release ...
Chitosan/alginate polyelectrolyte magnetic gel nanoarchitectonics with tunable ...
Veloso, Sérgio Rafael Silva; Vázquez-González, Margarita; Ribeiro, Mariana O.; Hilliou, L.; Amorim, Carlos O.; Amaral, Vítor S.Chitosan-based hydrogels hold promise as drug delivery systems for cancer therapy, but the poor mechanical properties often limit the biological application, requiring chemical cross-linking to improve sustained drug release. Besides, the addition of stimulus-responsiveness to chitosan requires chemical modifications that can further affect the gel properties. To overcome these challenges, in this work, a novel...
Amplified Sensitivity in SERS Detection of L1CAM With Silver Plasmonic Mesoporo...
Castaño-Guerrero, Yuselis; Arjones-Fernández, Belén; Moreira, Felismina T. C.; Alvarez-Puebla, Ramon A.; Correa-Duarte, Miguel A.; Águas, H.This study presents a novel approach for dual detection, leveraging a combination of a Raman reporter-bearing nanomaterial and molecular imprinting polymers (MIP). A core-shell Au-Ag nanoparticles (Au-Ag NPs) encapsulated in mesoporous silica nanocapsules (Au-Ag NCs) and a new MIP-based material targeting L1CAM are used. The MIP prepared via surface imprinting on a carbon screen-printed electrode (C-SPE) used t...
Radiotherapy metastatic prostate cancer cell lines treated with gold nanorods m...
Soares, Sílvia; Aires, Fátima; Monteiro, Armanda; Pinto, Gabriela; Faria, Isabel; Sales, Goreti; Correa-Duarte, Miguel A.; Guerreiro, SusanaMicroRNA (miRNA) modulation has been identified as a promising strategy for improving the response of human prostate cancer (PCa) to radiotherapy (RT). Studies have shown that mimics or inhibitors of miRNAs could modulate the sensitivity of PCa cells to RT. In addition, pegylated gold nanoparticles have been studied as a therapeutic approach to treat PCa cells and/or vehicles for carrying miRNAs to the inside o...
Eco-friendly synthesis of fluorescent cobalt-doped manganese ferrites for therm...
Veloso, Sérgio R. S.; Nereu, Sara F.; Amorim, Carlos O.; Amaral, Vítor S.; Correa-Duarte, Miguel A.; Castanheira, Elisabete M. S.The synthesis of high-quality nanoparticles for biomedical applications through environmentally friendly methods is a major challenging task. In this work, oxidative precipitation and a novel method, oxidative hydrothermal synthesis, are explored as one-pot eco-friendly synthesis routes to obtain single phase multicore-like and single-core citrate-stabilized cobalt and/or manganese-doped ferrite (CoxMn1-xFe2O4,...
Application of Gold Nanoparticles as Radiosensitizer for Metastatic Prostate Ca...
Soares, Sílvia; Faria, Isabel; Aires, Fátima; Monteiro, Armanda; Pinto, Gabriela; Sales, M. Goreti F.; Correa-Duarte, Miguel A.; Guerreiro, Susana G.More than 50% of all prostate cancer (PCa) patients are treated by radiotherapy (RT). Radioresistance and cancer recurrence are two consequences of the therapy and are related to dose heterogeneity and non-selectivity between normal and tumoral cells. Gold nanoparticles (AuNPs) could be used as potential radiosensitizers to overcome these therapeutic limitations of RT. This study assessed the biological interac...
Development of a novel electrochemical biosensor based on plastic antibodies fo...
Carvalho, Margarida; Rocha, Sandra Moreira; Barroca-Ferreira, Jorge; Maia, Claudio J.; Guillade, Lucía; Correa-Duarte, Miguel A.; Passarinha, Luís A.STEAP1 is a cell surface protein of the STEAP family whose main function focuses on intercellular communication and cell growth. STEAP1 is considered a promising putative biomarker and a candidate target for prostate cancer treatment. For specific and selective detection of STEAP1, a molecularly imprinted polymers (MIP) was developed on a screen-printed electrode (C-SPE) whose surface was modified with a nanoco...
Application of gold nanoparticles as radiosensitizer for metastatic prostate ca...
Soares, Sílvia; Faria, Isabel; Aires, Fátima; Monteiro, Armanda; Pinto, Gabriela; Sales, Maria Goreti; Correa-Duarte, Miguel A.; Guerreiro, Susana G.More than 50% of all prostate cancer (PCa) patients are treated by radiotherapy (RT). Radioresistance and cancer recurrence are two consequences of the therapy and are related to dose heterogeneity and non-selectivity between normal and tumoral cells. Gold nanoparticles (AuNPs) could be used as potential radiosensitizers to overcome these therapeutic limitations of RT. This study assessed the biological interac...
Chitosan/alginate nanogels containing multicore magnetic nanoparticles for deli...
Veloso, Sérgio Rafael Silva; Marta, Eva S.; Rodrigues, Pedro V.; Moura, Cacilda; Amorim, Carlos O.; Amaral, Vítor S.; Correa-Duarte, Miguel A.In this study, multicore-like iron oxide (Fe3O4) and manganese ferrite (MnFe2O4) nanoparticles were synthesized and combined with nanogels based on chitosan and alginate to obtain a multimodal drug delivery system. The nanoparticles exhibited crystalline structures and displayed sizes of 20 ± 3 nm (Fe3O4) and 11 ± 2 nm (MnFe2O4). The Fe3O4 nanoparticles showed a higher saturation magnetization and heating effic...
Application of gold nanoparticles as radiosensitizer for metastatic prostate ca...
Soares, Sílvia; Faria, Isabel; Aires, Fátima; Monteiro, Armanda; Pinto, Gabriela; Sales, Maria Goreti; Correa-Duarte, Miguel A.; Guerreiro, Susana G.More than 50% of all prostate cancer (PCa) patients are treated by radiotherapy (RT). Radioresistance and cancer recurrence are two consequences of the therapy and are related to dose heterogeneity and non-selectivity between normal and tumoral cells. Gold nanoparticles (AuNPs) could be used as potential radiosensitizers to overcome these therapeutic limitations of RT. This study assessed the biological interac...