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Comparison of Celsior and Perfadex lung preservation solutions in rat lungs sub...
Menezes, Arteiro Queiroz; Pêgo-Fernandes, Paulo Manuel; Cardoso, Paulo Francisco Guerreiro; Braga, Karina Andrighetti de OliveiraOBJECTIVE: This study evaluated the performance of lungs that were preserved with different solutions (Celsior, Perfadex or saline) in an ex vivo rat lung perfusion system. METHODS: Sixty Wistar rats were anesthetized, anticoagulated and randomized into three groups (n = 20). The rats were subjected to antegrade perfusion via the pulmonary artery with Perfadex, Celsior, or saline, followed by 6 or 12 hours of i...
The effects on mucociliary clearance of prednisone associated with bronchial se...
Braga, Karina Andrighetti de Oliveira; Nepomuceno, Natalia Aparecida; Correia, Aristides Tadeu; Jatene, Fabio Biscegli; Pêgo-Fernandes, Paulo ManuelOBJECTIVE: Infections have been and remain the major cause of morbidity and mortality after lung transplantation. Because mucociliary clearance plays an important role in human defense mechanisms, the influence of drugs on the mucociliary epithelium of patients undergoing lung transplantation must be examined. Prednisone is the most important corticosteroid used after lung transplantation. The aim of this study...
Effects of mycophenolate sodium on mucociliary clearance using a bronchial sect...
Silva, Viviane Ferreira Paes e; Pazetti, Rogerio; Soto, Sonia de Fatima; Siqueira, Mariana Moreira Quinhones; Correia, Aristides TadeuOBJECTIVE: To study the effects of mycophenolate sodium on mucociliary clearance. INTRODUCTION: Mycophenolate is one of the most commonly used immunosuppressive drugs in lung transplantation. Although its pharmacokinetic properties are well defined, its side effects on mucociliary clearance have not yet been studied. METHODS: Sixty rats were subjected to left bronchial section and anastomosis. The right bronchu...