3 documents found, page 1 of 1
Computationally-designed miniproteins showing neutralization activity against S...
Moreira, Pedro Daniel Martins; Parada, Mariana; Fernandes, Bárbara; Buga, Carolina C.; Teixeira, Rita I.; Oliveira, Christine; Buckley, Stephen MichaelAs the COVID-19 pandemic demonstrated, the need for robust antiviral therapies against SARS-CoV-2 remains substantial. A promising strategy to meet this demand is through the development of proteins tailored for enhanced binding affinity to crucial viral targets, such as epitopes located on their fusion proteins. Among these targets is the Spike proteins receptor binding domain (RBD), which interacts with the h...
Oligomerization Profile of Human Transthyretin Variants with Distinct Amyloidog...
Frangolho, Ana; Correia, Bruno E.; Vaz, Daniela C.; Almeida, Zaida L.; Brito, Rui M. M.One of the molecular hallmarks of amyloidoses is ordered protein aggregation involving the initial formation of soluble protein oligomers that eventually grow into insoluble fibrils. The identification and characterization of molecular species critical for amyloid fibril formation and disease development have been the focus of intense analysis in the literature. Here, using photo-induced cross-linking of unmodi...
Oligomerization Profile of Human Transthyretin Variants with Distinct Amyloidog...
Frangolho, Ana; Correia, Bruno E.; Vaz, Daniela C.; Almeida, Zaida L.; Brito, Rui M. M.One of the molecular hallmarks of amyloidoses is ordered protein aggregation involving the initial formation of soluble protein oligomers that eventually grow into insoluble fibrils. The identification and characterization of molecular species critical for amyloid fibril formation and disease development have been the focus of intense analysis in the literature. Here, using photo-induced cross-linking of unmodi...