9 documents found, page 1 of 1
Generation and proof-of-concept for allogeneic CD123 CAR-Delta One T (DOT) cell...
Sánchez Martínez, Diego; Tirado, Néstor; Mensurado, Sofia; Martínez-Moreno, Alba; Romecín, Paola; Gutiérrez Agüera, Francisco; Correia, Daniel V.Background: Chimeric antigen receptor (CAR)-T cells have emerged as a breakthrough treatment for relapse/refractory hematological tumors, showing impressive complete remission rates. However, around 50% of the patients relapse before 1-year post-treatment. T-cell 'fitness' is critical to prolong CAR-T persistence and activity. Allogeneic T cells from healthy donors are less dysfunctional or exhausted than autol...
Human γδ thymocytes are functionally immature and differentiate into cytotoxic ...
Ribot, Julie C.; Ribeiro, Sérgio T.; Correia, Daniel V.; Sousa, Ana E.; Silva-Santos, BrunoCytotoxicity and IFN-γ production by human γδ T cells underlie their potent antitumor functions. However, it remains unclear where and how human γδ T cells acquire these key effector properties. Given the recent disclosure of a major contribution of the thymus to murine γδ T cell functional differentiation, in this study we have analyzed a series of human pediatric thymuses. We found that ex vivo-isolated γδ th...
Differentiation of human peripheral blood Vδ1+ T cells expressing the natural c...
Correia, Daniel V.; Fogli, Manuela; Hudspeth, Kelly; da Silva, Maria Gomes; Mavilio, Domenico; Silva-Santos, BrunoThe success of cancer immunotherapy depends on productive tumor cell recognition by killer lymphocytes. γδ T cells are a population of innate-like lymphocytes endowed with strong, MHC-unrestricted cytotoxicity against tumor cells. This notwithstanding, we recently showed that a large proportion of human hematologic tumors is resistant to γδ peripheral blood lymphocytes (PBLs) activated with specific agonists to...
The MHC class Ib protein ULBP1 is a nonredundant determinant of leukemia/lympho...
Lança, Telma; Correia, Daniel V.; Moita, Catarina F.; Raquel, Helena; Neves-Costa, Ana; Ferreira, Cristina; Ramalho, José S.; Barata, João T.On the path to successful immunotherapy of hematopoietic tumors, gamma-delta T cells offer great promise because of their human leukocyte antigen (HLA)-unrestricted targeting of a wide variety of leukemias/lymphomas. However, the molecular mechanisms underlying lymphoma recognition by gamma-delta T cells remain unclear. Here we show that the expression levels of UL16-binding protein 1 (ULBP1) determine lymphoma...
Identification of a panel of ten cell surface protein antigens associated with ...
Gomes, Anita Q.; Correia, Daniel V.; Grosso, Ana R.; Lanca, Telma; Ferreira, Cristina; Lacerda, João F.; Barata, João T.; Silva, Maria Gomes daBackground: Vγ9Vδ2 T lymphocytes are regarded as promising mediators of cancer immunotherapy due to their capacity to eliminate multiple experimental tumors, particularly within those of hematopoietic origin. However, Vγ9Vδ2 T-cell based lymphoma clinical trials have suffered from the lack of biomarkers that can be used as prognostic of therapeutic success. Design and Methods: We have conducted a comprehensive ...
The MHC class Ib protein ULBP1 is a nonredundant determinant of leukemia/lympho...
Lança, Telma; Correia, Daniel V.; Moita, Catarina F.; Raquel, Helena; Neves-Costa, Ana; Ferreira, Cristina; Ramalho, José S.; Barata, João T.On the path to successful immunotherapy of hematopoietic tumors, γδ T cells offer great promise because of their human leukocyte antigen (HLA)–unrestricted targeting of a wide variety of leukemias/lymphomas. However, the molecular mechanisms underlying lymphoma recognition by γδ T cells remain unclear. Here we show that the expression levels of UL16-binding protein 1 (ULBP1) determine lymphoma susceptibility to...
Inhibition of murine γδ lymphocyte expansion and effector function by regulator...
Gonçalves-Sousa, Natacha; Ribot, Julie C.; Barros, Ana de; Correia, Daniel V.; Caramalho, Íris; Silva-Santos, Brunoγδ T cells are highly cytolytic lymphocytes that produce large amounts of pro-inflammatory cytokines during immune responses to multiple pathogens. Furthermore, their ability to kill tumor cells has fueled the development of γδ-T-cell-based cancer therapies. Thus, the regulation of γδ-T-cell activity is of great biological and clinical relevance. Here, we show that murine CD4+CD25+ αβ T cells, the vast majority...
Identification of a panel of ten cell surface protein antigens associated with ...
Gomes, Anita Q.; Correia, Daniel V.; Grosso, Ana R.; Lança, Telma; Ferreira, Cristina; Lacerda, João F.; Barata, João T.; Gomes da Silva, MariaBackground Vγ9Vδ2 T lymphocytes are regarded as promising mediators of cancer immunotherapy due to their capacity to eliminate multiple experimental tumors, particularly within those of hematopoietic origin. However, Vγ9Vδ2 T-cell based lymphoma clinical trials have suffered from the lack of biomarkers that can be used as prognostic of therapeutic success. Design and Methods We have conducted a comprehensive st...
Non‐classical major histocompatibility complex proteins as determinants of tumo...
Gomes, Anita Q.; Correia, Daniel V.; Silva-Santos, BrunoTumours develop in vertebrate organisms endowed with immune systems that are potentially able to eradicate them. Nevertheless, our ever-increasing understanding of the complex interactions between lymphocytes and tumour cells fuels the long-standing hope of developing efficient immunotherapies against cancer. This review focuses on a versatile family of proteins, the major histocompatibility complex class Ib, w...