16 documents found, page 1 of 2
Retinal pigment epithelium-derived extracellular vesicles mediate outer blood r...
Martins, Beatriz; Boia, Raquel; Correia, Diana; Ribeiro-Rodrigues, Teresa; Ramalho, José; Ambrósio, António Francisco; Girão, Henrique; Fernandes, RosaBackground: Age-related macular degeneration (AMD) is a leading cause of vision loss among the elderly, primarily affecting the central vision. This progressive degenerative disease is characterized by the dysregulation and degeneration of the retinal pigment epithelium (RPE), a crucial cell layer beneath the photoreceptors that maintains outer retinal homeostasis. Emerging evidence suggests that during AMD, st...
Radiation-induced pneumonitis: literature review and clinical case
Correia, Diana; Nobre Góis, Inês; Abreu, André; Borrego, MargaridaIntroduction and Objectives: Most cancer patients need radiotherapy treatments. In chest irradiation, a possible serious complication is Radiation-Induced lung Injury, an entity that encompasses radiation-induced pneumonitis and radiation fibrosis. Radiation-induced pneumonitis occurs in 5-20% of patients and may be asymptomatic or symptomatic, which can affect the quality of life of patients. Materials and Met...
The Impact of BDNF, NTRK2, NGFR, CREB1, GSK3B, AKT, MAPK1, MTOR, PTEN, ARC, and...
Santos, Marlene; Lima, Luis; CARVALHO, SERAFIM; Mota-Pereira, Jorge; Pimentel, Paulo; Maia, Dulce; Correia, Diana; Barroso, M. Fátima; Gomes, SofiaThis study aimed to investigate the influence of genetic variants in neuroplasticity-related genes on antidepressant treatment phenotypes. The BDNF-TrkB signaling pathway, as well as the downstream kinases Akt and ERK and the mTOR pathway, have been implicated in depression and neuroplasticity. However, clinicians still struggle with the unpredictability of antidepressant responses in depressed patients. We gen...
The impact of BDNF, NTRK2, NGFR, CREB1, GSK3B, AKT, MAPK1, MTOR, PTEN, ARC, and...
Santos, Marlene; Lima, Luis; Carvalho, Serafim; Mota-Pereira, Jorge; Pimentel, Paulo; Maia, Dulce; Correia, Diana; Barroso, M. Fátima; Gomes, SofiaThis study aimed to investigate the influence of genetic variants in neuroplasticity-related genes on antidepressant treatment phenotypes. The BDNF-TrkB signaling pathway, as well as the downstream kinases Akt and ERK and the mTOR pathway, have been implicated in depression and neuroplasticity. However, clinicians still struggle with the unpredictability of antidepressant responses in depressed patients. We gen...
The needs of children receiving end of life care and the impact of a paediatric...
Nogueira, Andreia; Correia, Diana; Loureiro, Marisa; Gomes, Bárbara; Cancelinha, CândidaPublished data collected in hospital during the last year of life of children with life-limiting complex chronic conditions (CCC) is scarce, yet critical, for the implementation of paediatric palliative care (PPC). This study aims to describe the last year of life of children with CCC, in terms of clinical characteristics, hospital resources and the impact of referral to a hospital-based PPC team (PPCT). Using ...
Influence of the nurse-patient ratio on physical restraint in psychiatry: syste...
Matos, Ricardo; Cruz, Ana; Ferreira, Bruna; Gonçalves, Carla; Correia, Diana; Almeida, EmanuelBackground: physical restraint in psychiatric services is a common practice, which can compromise a person’s freedom, self-determination, dignity and life. Associated with efforts to minimize the use of this measure, the nurse-patient ratio factor has been little studied. Objective: to analyze the influence of the nurse-patient ratio in psychiatric services on the use of physical restraint and isolation. Method...
Communicating in a mobile, connected world: the impact of digital transformatio...
Simões, Anabela; Correia, Diana; Miranda, MariaThe main objective of the present work is to analyse the impact of digital transformation on the University of Aveiro (UA), with a special focus on the communication platforms and tools that allow students and staff faster and easier access to information, as well as to a wide range of services such as, for example, cloud housing/hosting, information storage space or academic software licensing. Furthermore, wi...
The role of IL18-607C > A and IL18-137G > C promoter polymorphisms in antidepre...
Santos, Marlene; Carvalho, Serafim; Lima, Luís; Mota-Pereira, Jorge; Pimentel, Paulo; Maia, Dulce; Correia, Diana; Gomes, Sofia; Cruz, AgostinhoRecent studies suggest that immune activation and cytokines, such as IL-18, are involved in depression. IL-18 is expressed in brain and is increased in patients with moderate to severe depression. In this study we aim to evaluate the role of IL18-607C > A and IL18-137G > C promoter polymorphisms in antidepressant treatment phenotypes, specifically relapse and treatment resistant depression (TRD). We genotyped t...
IL6-174G > C genetic polymorphism influences antidepressant treatment outcome
Carvalho, Serafim; Santos, Marlene; Lima, Luís; Mota-Pereira, Jorge; Pimentel, Paulo; Maia, Dulce; Correia, Diana; Gomes, Sofia; Cruz, AgostinhoMajor depressive disorder is a condition associated with dysregulated cytokine levels; among these, IL6. Furthermore, genetic variations within cytokine genes have been proposed to predict antidepressant treatment outcome. This study aims to evaluate the role of IL6-174G > C and IL6R D358A A > C functional poly-morphisms in antidepressant treatment phenotypes, specifically remission, relapse, and treatment resi...
FAS -670A>G genetic polymorphism Is associated with treatment resistant depression
Santos, Marlene; Carvalho, Serafim; Lima, Luís; Mota-Pereira, Jorge; Pimentel, Paulo; Maia, Dulce; Correia, Diana; Gomes, Sofia; Cruz, AgostinhoHippocampal neurogenesis has been suggested as a downstream event of antidepressants (AD) mechanism of action and might explain the lag time between AD administration and the therapeutic effect. Despite the widespread use of AD in the context of Major Depressive Disorder (MDD) there are no reliable biomarkers of treatment response phenotypes, and a significant proportion of patients display Treatment Resistant ...