87 documents found, page 1 of 9
Hyaluronic acid-functionalized graphene-based nanohybrids for targeted breast c...
Lima-Sousa, Rita; Melo, Bruna L.; Mendonça, António; Correia, I.J.; Melo-Diogo, Duarte deNanomaterials’ application in cancer therapy has been driven by their ability to encapsulate chemotherapeutic drugs as well as to reach the tumor site. Nevertheless, nanomedicines’ translation has been limited due to their lack of specificity towards cancer cells. Although the nanomaterials’ surface can be coated with targeting ligands, such has been mostly achieved through non-covalent functionalization strate...
Development of dual-crosslinked Pluronic F127/Chitosan injectable hydrogels inc...
Pouso, Manuel António do Rosário; Melo, Bruna L.; Gonçalves, Joaquim; Mendonça, António; Correia, I.J.; Diogo, Duarte de MeloNanomaterials with responsiveness to near-infrared light can mediate the photoablation of cancer cells with an exceptional spatio-temporal resolution. However, the therapeutic outcome of this modality is limited by the nanostructures’ poor tumor uptake. To address this bottleneck, it is appealing to develop injectable in situ forming hydrogels due to their capacity to perform a tumor-confined delivery of the na...
Application of near-infrared light responsive biomaterials for improving the wo...
Graça, Mariana F. P.; Moreira, André F.; Correia, I.J.Despite aiming to improve the healing process, the wound dressings that have been developed thus far still present high production costs, uncontrolled drug delivery, and are unable to fully re-establish all features of native skin. In this field, the development of light-responsive dressings has been emerging due to the possibility of controlling the delivery of therapeutic agents both in time and space. Moreov...
Reduced graphene oxide–reinforced tricalcium phosphate/gelatin/chitosan light-r...
Cabral, Cátia S. D.; Melo-Diogo, Duarte de; Ferreira, Paula; Moreira, André F.; Correia, I.J.Bone is a mineralized tissue with the intrinsic capacity for constant remodeling. Rapid prototyping techniques, using biomaterials that mimic the bone native matrix, have been used to develop osteoinductive and osteogenic personalized 3D structures, which can be further combined with drug delivery and phototherapy. Herein, a Fab@Home 3D Plotter printer was used to promote the layer-by-layer deposition of a comp...
Red blood cell membrane-camouflaged gold-core silica shell nanorods for cancer ...
Rodrigues, Ana Carolina F.; Correia, I.J.; Moreira, André F.Gold core mesoporous silica shell (AuMSS) nanorods are multifunctional nanomedicines that can act simultaneously as photothermal, drug delivery, and bioimaging agents. Nevertheless, it is reported that once administrated, nanoparticles can be coated with blood proteins, forming a protein corona, that directly impacts on nanomedicines’ circulation time, biodistribution, and therapeutic performance. Therefore, it...
Preparation of Gel Forming Polymer-Based Sprays for First Aid Care of Skin Inju...
Alves, Patrícia; Luzio, Diana; Sá, Kevin; Correia, I.J.; Ferreira, PaulaCurrently, there are several types of materials for the treatment of wounds, burns, and other topical injuries available on the market. The most used are gauzes and compresses due to their fluid absorption capacity; however, these materials adhere to the surface of the lesions, which can lead to further bleeding and tissue damage upon removal. In the present study, the development of a polymer-based gel that ca...
Silica Aerogel-Polycaprolactone Scaffolds for Bone Tissue Engineering
Pontinha, Ana; Moreira, Eliana Barbosa Da Silva; Melo, Bruna L.; Melo-Diogo, Duarte de; Correia, I.J.; Alves, PatríciaSilica aerogel is a material composed of SiO2 that has exceptional physical properties when utilized for tissue engineering applications. Poly-ε-caprolactone (PCL) is a biodegradable polyester that has been widely used for biomedical applications, namely as sutures, drug carriers, and implantable scaffolds. Herein, a hybrid composite of silica aerogel, prepared with two different silica precursors, tetraethoxys...
Poly(2-ethyl-2-oxazoline)–IR780 conjugate nanoparticles for breast cancer photo...
Alves, Cátia; Lima-Sousa, Rita; Melo, Bruna L.; Ferreira, Paula; Moreira, André; Correia, I.J.; de Melo-Diogo, DuarteConventional anticancer approaches are often associated with severe side effects. Herein, the authors assembled a novel nanoparticle whose therapeutic effect is triggered by laser light. In in vitro assays, the produced nanomaterial was able to, after interacting with laser light, reduce the viability of classic and advanced cancer models. In these conditions, but in the absence of laser light, no cytotoxicity ...
Sulfobetaine methacrylate-coated reduced graphene oxide-IR780 hybrid nanosystem...
Melo, Bruna L.; Lima-Sousa, Rita; Alves, Cátia; Correia, I.J.; de Melo-Diogo, DuarteNanomaterials with near infrared light absorption can mediate an antitumoral photothermal-photodynamic response that is weakly affected by cancer cells’ resistance mechanisms. Such nanosystems are commonly prepared by loading photosensitizers into nanomaterials displaying photothermal capacity, followed by functionalization to achieve biological compatibility. However, the translation of these multifunctional n...
Injectable hydrogels for the delivery of nanomaterials for cancer combinatorial...
Lima-Sousa, Rita; Alves, Cátia; Melo, Bruna L.; Costa, Francisco J. P.; Nave, Micaela; Moreira, André F.; Mendonça, António; Correia, I.J.Progress in the nanotechnology field has led to the development of a new class of materials capable of producing a temperature increase triggered by near infrared light. These photothermal nanostructures have been extensively explored in the ablation of cancer cells. Nevertheless, the available data in the literature have exposed that systemically administered nanomaterials have a poor tumor-homing capacity, hi...