28 documents found, page 1 of 3
Optimization of the GSH-Mediated Formation of Mesoporous Silica-Coated Gold Nan...
Fernandes, Natanael; Rodrigues, Carolina F; de Melo-Diogo, Duarte; Correia, Ilídio J.; Moreira, André FCancer light-triggered hyperthermia mediated by nanomaterials aims to eliminate cancer cells by inducing localized temperature increases to values superior to 42 °C, upon irradiation with a laser. Among the different nanomaterials with photothermal capacity, the gold-based nanoparticles have been widely studied due to their structural plasticity and advantageous physicochemical properties. Herein, a novel and s...
Electrospun Asymmetric Membranes as Promising Wound Dressings: A Review
Graça, Mariana F. P.; de Melo-Diogo, Duarte; Correia, Ilídio J.; Moreira, André F.Despite all the efforts that have been done up to now, the currently available wound dressings are still unable to fully re-establish all the structural and functional properties of the native skin. To overcome this situation, researchers from the tissue engineering area have been developing new wound dressings (hydrogels, films, sponges, membranes) aiming to mimic all the features of native skin. Among them, a...
Influence of ClearT and ClearT2 Agitation Conditions in the Fluorescence Imagin...
Silva, Daniel N.; Costa, Elisabete C.; Rodrigues, Carolina F.; de Melo-Diogo, Duarte; Correia, Ilídio J.; Moreira, André F.3D tumor spheroids have arisen in the last years as potent tools for the in vitro screening of novel anticancer therapeutics. Nevertheless, to increase the reproducibility and predictability of the data originated from the spheroids it is still necessary to develop or optimize the techniques used for spheroids' physical and biomolecular characterization. Fluorescence microscopy, such as confocal laser scanning ...
Photocurable Polymeric Blends for Surgical Application
Cernadas, Teresa; Santos, Marta; Miguel, Sónia P.; Correia, Ilídio J.; Alves, Patrícia; Ferreira, PaulaThe preparation of photocrosslinkable bioadhesives synthesized from oligomers of lactic acid and polycaprolactone (PCL), both functionalized with 2-isocyanoethyl acrylate (AOI), were studied. The obtained modified macromers of LA-AOI (mLA) and PCL-AOI (mCL) were chemically characterized by 1H NMR and used to formulate polymeric blends with different mass proportions, 1:1, 1:2 and 2:1, respectively. Subsequently...
Xanthan Gum-Konjac Glucomannan Blend Hydrogel for Wound Healing
Alves, Andreia; Miguel, Sónia P.; Araujo, André R. T. S.; de Jesús Valle, María José; Sánchez Navarro, Amparo; Correia, Ilídio J.; Ribeiro, Maximiano P.Hydrogels are considered to be the most ideal materials for the production of wound dressings since they display a three-dimensional structure that mimics the native extracellular matrix of skin as well as a high-water content, which confers a moist environment at the wound site. Until now, different polymers have been used, alone or blended, for the production of hydrogels aimed for this biomedical application...
Sulfobetaine methacrylate-functionalized graphene oxide-IR780 nanohybrids aimed...
Leitão, Miguel M.; Alves, Cátia G.; de Melo-Diogo, Duarte; Lima-Sousa, Rita; Moreira, André F.; Correia, Ilídio J.The application of Graphene Oxide (GO) in cancer photothermal therapy is hindered by its lack of colloidal stability in biologically relevant media and modest Near Infrared (NIR) absorption. In this regard, the colloidal stability of GO has been improved by functionalizing its surface with poly(ethylene glycol) (PEG), which may not be optimal due to the recent reports on PEG immunogenicity. On the other hand, t...
Photocrosslinkable Nanofibrous Asymmetric Membrane Designed for Wound Dressing
Alves, Patrícia; Santos, Marta; Mendes, Sabrina; Miguel, Sónia P.; Sá, Kevin D. de; Cabral, Cátia S. D.; Correia, Ilídio J.; Ferreira, PaulaRecently, the biomedical scientists who are working in the skin regeneration area have proposed asymmetric membranes as ideal wound dressings, since they are able to reproduce both layers of skin and improve the healing process as well as make it less painful. Herein, an electrospinning technique was used to produce new asymmetric membranes. The protective layer was composed of a blending solution between polyc...
Bioinspired multilayer membranes as potential adhesive patches for skin wound h...
Sousa, Maria P.; Neto, Ana I.; Correia, Tiago R.; Miguel, Sónia P.; Matsusaki, Michiya; Correia, Ilídio J.; Mano, João F.Bioinspired and adhesive multilayer membranes are produced using the layer-by-layer (LbL) assembly of chitosan (CHT), alginate (ALG) and hyaluronic acid modified with dopamine (HA-DN). Freestanding multilayer membranes without DN are also produced as a control. The success of the synthesis of HA-DN was confirmed using UV-visible spectroscopy. Scanning electron microscopy images indicate that the surface of the ...
Recent advances on antimicrobial wound dressing: A review
Simões, Déborah; Miguel, Sónia P.; Ribeiro, Maximiano P.; Coutinho, Paula; Mendonça, António G.; Correia, Ilídio J.Skin and soft tissue infections (SSTIs) have high rates of morbidity and mortality associated. Despite the successful treatment of some SSTIs, those affecting the subcutaneous tissue, fascia, or muscle delay the healing process and can lead to life-threatening conditions. Therefore, more effective treatments are required to deal with such pathological situations. Recently, wound dressings loaded with antimicrob...
Electrospun polymeric nanofibres as wound dressings: A review
Miguel, Sónia P.; Figueira, Daniela R.; Simões, Déborah; Ribeiro, Maximiano P.; Coutinho, Paula; Ferreira, Paula; Correia, Ilídio J.Skin wounds have significant morbidity and mortality rates associated. This is explained by the limited effectiveness of the currently available treatments, which in some cases do not allow the reestablishment of the structure and functions of the damaged skin, leading to wound infection and dehydration. These drawbacks may have an impact on the healing process and ultimately prompt patients’ death. For this re...