Condenado o rio Doce pela poluição e bloqueado o acesso pela estrada de ferro, a aproximação a Maria Ortiz faz-se por pista de terra, comprimida entre o rio e os trilhos, em Colatina, estado do Espírito Santo, Brasil. O objetivo é debater a configuração da paisagem alterada por interesses econômicos, provocando mudanças comportamentais, destacando o núcleo de implantação urbana e as principais linhas de desenho...
Este artigo propõe debater resultados da análise da configuração da paisagem atual de Itapina, município de Colatina, estado do Espírito Santo, Brasil, com destaque para o seu núcleo principal de ocupação, com vistas ao estabelecimento de referenciais que possam ser considerados em projetos futuros de qualificação urbana do lugar. Com base na primeira etapa do projeto de investigação: ‘Transformação da paisagem...
Background: Substantial improvements in survival have been observed in HER2 (human epidermal growth factor receptor 2)-positive (HER2+) inoperable or metastatic breast cancer (advanced breast cancer [ABC]) in recent years, driven by the introduction and widespread use of multiple novel agents. The DESTINY-Breast02 trial compared the efficacy and safety of trastuzumab deruxtecan (T-DXd) in patients with HER2+ AB...
Introduction: Upper tract urothelial carcinoma is an infrequent but aggressive disease. Radical nephroureterectomy is the standard of care for nonmetastatic tumors. The potential implications of old age in the management of upper tract urothelial carcinoma are still controversial. Our aim was to analyze the effect of old age on peri-operative and oncological outcomes after radical nephroureterectomy. Methods: W...
Background: Half of all breast cancer (BC) cases fall into the HER2-low category, defined as immunohistochemistry (IHC) 1+ or IHC 2+ in situ hybridization negative (ISH-). Two-thirds of these cases are IHC1+, while one-third is IHC2+/ISH-. New anti-HER2 antibody-drug conjugates (ADCs) have emerged as treatment options for metastatic or unresectable HER2-low BC patients. However, the heterogeneity between IHC1+ ...
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This paper examines the impact of cultural factors, primarily religion, on the morphology of historic villages in central Iran. The study combines a literature review with a qualitative research methodology that involves interviews and site visits. The research investigates how various cultural and religious beliefs, customs, traditions, and ceremonies have influenced the physical landscape of villages and thei...
In 1415, Portugal started a series of occupations in North Africa. This process extended until 1769 and also included new settlements. The act of consecration of the Main Mosque became one of the strongest symbols of the faith paradigm shift inherent to the change of sovereignty. With it, the most pragmatic aspects of the Portuguese occupation were applied: the immediate appropriation and transformation of reli...
Adenoviruses (AdV) are pathogens capable of infecting animals and humans leading to a wide spectrum of diseases. They have a widespread geographical dissemination and infect several species, including red squirrels (Sciurus vulgaris ). In the Iberian Peninsula, there are no reports of infection of red squirrels by AdV. In this study, we report for the first time the detection of squirrel AdV in a red squirrel t...
[Excerto] O Lab2PT - Laboratório de Paisagens, Património e Território - apresenta-se como uma unidade de investigação com forte propensão para a investigação aplicada e prestação de serviços com elevado nível de impacto social. Atuando por entre várias áreas do saber, da arqueologia ao design ou às artes visuais, da geografia à história ou às ciências da terra, recebe da arquitetura e do urbanismo uma das suas...