3 documents found, page 1 of 1
Age-associated metabolic and epigenetic barriers during direct reprogramming of...
Santos, Francisco; Correia, Magda; Dias, Rafaela; Bola, Bárbara; Noberini, Roberta; Ferreira, Rita S.; Trigo, Diogo; Domingues, Pedro; Teixeira, JoséHeart disease is the leading cause of mortality in developed countries, and novel regenerative procedures are warranted. Direct cardiac conversion (DCC) of adult fibroblasts can create induced cardiomyocytes (iCMs) for gene and cell-based heart therapy, and in addition to holding great promise, still lacks effectiveness as metabolic and age-associated barriers remain elusive. Here, by employing MGT (Mef2c, Gata...
Metabolic determinants in cardiomyocyte function and heart regenerative strategies
Correia, Magda; Santos, Francisco; Ferreira, Rita da Silva; Ferreira, Rita; Jesus, Bruno Bernardes de; Nóbrega-Pereira, SandrinaHeart disease is the leading cause of mortality in developed countries. The associated pathology is characterized by a loss of cardiomyocytes that leads, eventually, to heart failure. In this context, several cardiac regenerative strategies have been developed, but they still lack clinical effectiveness. The mammalian neonatal heart is capable of substantial regeneration following injury, but this capacity is l...
Age-related pathways in cardiac regeneration : a role for lncRNAs?
Santos, Francisco; Correia, Magda; Nóbrega-Pereira, Sandrina; Bernardes de Jesus, BrunoAging imposes a barrier for tissue regeneration. In the heart, aging leads to a severe rearrangement of the cardiac structure and function and to a subsequent increased risk of heart failure. An intricate network of distinct pathways contributes to age-related alterations during healthy heart aging and account for a higher susceptibility of heart disease. Our understanding of the systemic aging process has alre...