Generalized pustular psoriasis (GPP) is a rare but severe inflammatory skin disease characterized by the eruption of widespread sterile pustules, often accompanied by systemic inflammation. Although GPP can coexist with plaque psoriasis, it is increasingly recognized as a distinct entity with unique clinicopathological, immunologic, and genetic features. The dysregulated IL-36 pathway, including mutations in th...
Introduction: Psoriasis is a common, chronic, and inflammatory skin disorder with a high personal, social and economic burden and important implications for healthcare systems. The aim of this study was to provide an epidemiological characterization of individuals with psoriasis in Portugal.Material and Methods: A large observational, cross-sectional, nationwide, population-based survey study developed by the P...
Introduction: Psoriasis is a common, chronic, and inflammatory skin disorder with a high personal, social and economic burden and important implications for healthcare systems. The aim of this study was to provide an epidemiological characterization of individuals with psoriasis in Portugal. Methods: A large observational, cross-sectional, nationwide, population-based survey study developed by the Portuguese Ps...
Introduction: Psoriasis is a common, chronic, and inflammatory skin disorder with a high personal, social and economic burden and important implications for healthcare systems. The aim of this study was to provide an epidemiological characterization of individuals with psoriasis in Portugal. Material and methods: A large observational, cross-sectional, nationwide, population-based survey study developed by the ...
Introduction: Nonmelanoma skin cancer (NMSC) is one of the most frequent cancers worldwide, with 7.7 million incident cases estimated in 2017 by the Global Burden of Disease Cancer Collaboration. In this study, we have estimated the prevalence and mortality associated with NMSC in mainland Portugal, through the adaptation and validation of an economic decision model integrating the various disease states of NMS...
Introduction: Non-melanoma skin cancer (NMSC) includes several types of skin cancer, with the most common types of tumors being basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The current study aims to describe the landscape of NMSC in Portugal, based on real world data from both the public and private sectors.Methods: Two sub-studies are included in this work. In sub-study one, hospital episode s...
Introduction: The incidence of skin cancer has been increasing in recent years around the world. Key targets in the fight against skin cancer include alerting populations to primary prevention by promoting knowledge about risk factors and encouraging better sun protection behaviors as well as secondary prevention promoting skin self-examination and screenings. The Portuguese Society of Dermatology and Venereolo...
Every minute, three to six people in the world discover they have skin cancer. That's two to three million people a year, according to the World Health Organization. In the case of melanomas, the numbers point to 123 thousand cases, annually. In Portugal, 12 thousand new cases of skin cancer (melanomas and non-melanomas) are estimated every year. These neoplasms are the most frequent in Caucasian individuals an...
Introdução: O Síndroma de Buschke Ollendorff (SBO) é uma entidade rara de transmissão autossómica dominante caracterizada por nevos de tecido conjuntivo e osteopoiquilose. Resulta de uma mutação com perda de função do gene LEMD3 que codifica uma proteína reguladora negativa do fator de transformação de crescimento β e da proteína óssea morfogénica. Caso Clínico: Criança do sexo masculino, 7 anos de idade, previ...
Background: Atopic dermatitis (AD) patients may benefit from using textiles coated with skin microbiome-modulating compounds. Chitosan, a natural biopolymer with immunomodulatory and antimicrobial properties, has been considered potentially useful. Objective: This randomized controlled trial assessed the clinical utility of chitosan-coated garment use in AD. Methods: Of the 102 patients screened, 78 adult and a...