45 documents found, page 1 of 5
The influence of feeder cell-derived extracellular matrix density on thymic epi...
Silva, Catarina S.; Pinto, Rute D.; Pires, R. A.; Correia-Neves, M; Reis, R. L.; Alves, Nuno L.; Martins, Albino; Neves, N. M.The thymus is responsible for the selection and development of T cells, having an essential role in the establishment of adaptive immunity. Thymic epithelial cells (TECs) are key players in T cell development interacting with thymocytes in the thymic 3D environment. Feeder-layer cells have been frequently used as platforms for the successful establishment of TEC cultures. Nevertheless, the role of the feeder ce...
Exploring the diversity of visceral, subcutaneous and perivascular adipose tiss...
Ferreira, Joana; Afonso, Julieta Alexandra Pereira; Carneiro, Alexandre Lima; Vila, Isabel; Cunha, Cristina; Roque, Susana; Silva, CristinaThe prevalence of obesity has doubled, with a concomitant increase in cardiovascular disease. This study aimed to compare the characteristics of visceral, subcutaneous and peri-aortic adipose tissue determined with computed tomography (CT) scans and to correlate them with cardiovascular risk factors, anthropometric measures and medication. An observational and prospective study was conducted, and 177 subjects w...
Is obesity a risk factor for carotid atherosclerotic disease?—opportunistic review
Ferreira, Joana; Cunha, Pedro; Carneiro, Alexandre; Vila, Isabel; Cunha, Cristina; Silva, Cristina; Longatto, Adhemar; Mesquita, Amílcar; Cotter, JorgeObesity is a risk factor for coronary atherosclerosis. However, the influence of adipose tissue in carotid atherosclerosis is not completely understood. No systematic review/meta-analysis was previously performed to understand if obesity is a risk factor for carotid atherosclerosis. This paper aims to provide an opportunistic review of the association between obesity and carotid atherosclerosis and define the r...
Intra-urban variation in tuberculosis and community socioeconomic deprivation i...
Oliveira, O; Ribeiro, AI; Duarte, R; Correia-Neves, M; Rito, TBackground: Multidrug resistant tuberculosis (MDR-TB) is a recognized threat to global efforts to TB control and remains a priority of the National Tuberculosis Programs. Additionally, social determinants and socioeconomic deprivation have since long been associated with worse health and perceived as important risk factors for TB. This study aimed to analyze the spatial distribution of non-MDR-TB and MDR-TB acr...
IFNγ and iNOS-Mediated Alterations in the Bone Marrow and Thymus and Its Impact...
Barreira-Silva, P; Melo-Miranda, R; Nobrega, C; Roque, S; Serre-Miranda, C; Borges, M; Armada, G; Calçada, DS; Behar, SM; Appelberg, R; Correia-Neves, MDisseminated infection with the high virulence strain of Mycobacterium avium 25291 leads to progressive thymic atrophy. We previously showed that M. avium-induced thymic atrophy results from increased glucocorticoid levels that synergize with nitric oxide (NO) produced by interferon gamma (IFNg) activated macrophages. Where and how these mediators act is not understood.We hypothesized that IFNg and NO promote t...
Evaluation of drug-resistant tuberculosis treatment outcome in Portugal, 2000-2016
Oliveira, O; Gaio, R; Correia-Neves, M; Rito, T; Duarte, RTreatment of drug-resistant tuberculosis (TB), which is usually less successful than that of drug-susceptible TB, represents a challenge for TB control and elimination. We aimed to evaluate treatment outcomes and to identify the factors associated with death among patients with MDR and XDR-TB in Portugal. We assessed MDR-TB cases reported for the period 2000-2016, using the national TB Surveillance System. Trea...
Quantification of the animal tuberculosis multi-host community offers insights ...
Santos, Nuno; Richomme, Céline; Nunes, Telmo; Vicente, Joaquín; Alves, Paulo C.; de la Fuente, José; Correia-Neves, M; Boschiroli, María-LauraAnimal tuberculosis (TB) is a multi-host zoonotic disease whose prevalence in cattle herds in Europe has been increasing, despite a huge investment in eradication. The composition of the host community is a fundamental driver of pathogen transmission, and yet this has not been formally quantified for animal TB in Europe. We quantified multi-host communities of animal TB, using stochastic models to estimate the ...
Phylogeography of 27,000 SARS-CoV-2 genomes: Europe as the major source of the ...
Rito, Teresa S; Richards, Martin B.; Pala, Maria; Correia-Neves, M; Soares, PedroThe novel coronavirus SARS-CoV-2 emerged from a zoonotic transmission in China towards the end of 2019, rapidly leading to a global pandemic on a scale not seen for a century. In order to cast fresh light on the spread of the virus and on the effectiveness of the containment measures adopted globally, we used 26,869 SARS-CoV-2 genomes to build a phylogeny with 20,247 mutation events and adopted a phylogeographi...
Sarcopenia and atherosclerotic occlusive disease: how much we know and what we ...
Ferreira, Joana; Carneiro, Alexandre; Cunha, Pedro; Mansilha, Armando; Vila, Isabel; Cunha, Cidália Cristina Ferreira da; Silva, CristinaPurpose/Background: Sarcopenia (decrease of muscle mass and function) has been linked with atherosclerosis [1]. The EWGSOP2 updated consensus, uses low muscle strength as the primary indicator of sarcopenia [2]. It is acknowledged that strength is better than mass for predicting adverse outcomes [2]. Handgrip strength (HGS) is a simple assessment to estimate overall muscular strength [3]. and is associated with...
Livro GIRO: Mais perto de si, para si, seja GIRO connosco
Quialheiro, Anna; Castanho, Teresa Costa; Rodrigues, Ana João; Santos, Nadine Correia; Correia-Neves, MO Projeto GIRO, é uma iniciativa do Centro de Medicina Digital P5 da Escola de Medicina da Universidade do Minho, que serve como uma plataforma gratuita onde partilhamos atividades de exercício físico, de estimulação cognitiva e recreativas, bem como a promoção de hábitos alimentares saudáveis, para a população sénior. A metodologia GIRO é composta por atividades distribuídas ao longo da semana que envolvem: Ge...