4 documents found, page 1 of 1
Thymic Function as a Predictor of Immune Recovery in Chronically HIV-Infected P...
Rb-Silva, R.; Nobrega, C.; Azevedo, C.; Athayde, E.; Canto-Gomes, J.; Ferreira, I.; Cheynier, R.; Yates, A.; Horta, Ana; Correia-Neves, M.Poor immunological responders (PIR) are HIV-infected patients with virologic suppression upon antiretroviral therapy (ART) but persistently low CD4+ T cell counts. Early identification of PIR is important given their higher morbimortality compared to adequate immune responders (AIR). In this study, 33 patients severely lymphopenic at ART onset, were followed for at least 36 months, and classified as PIR or AIR ...
Toxoplasmosis-associated IRIS involving the CNS: a case report with longitudina...
Rb-Silva, R.; Nobrega, C.; Reiriz, E.; Almeida, S.; Sarmento-Castro, R.; Correia-Neves, M.; Horta, A.BACKGROUND: HIV-infected patients may present an unforeseen clinical worsening after initiating antiretroviral therapy known as immune reconstitution inflammatory syndrome (IRIS). This syndrome is characterized by a heightened inflammatory response toward infectious or non-infectious triggers, and it may affect different organs. Diagnosis of IRIS involving the central nervous system (CNS-IRIS) is challenging du...
Absence of IFN gamma promotes hippocampal plasticity and enhances cognitive per...
Monteiro, S.; Ferreira, F. M.; Pinto, V.; Roque, Susana; Morais, M; Calçada, Daniela Alexandra Sá; Mota, C.; Correia-Neves, M.; Cerqueira, João JoséCognitive functioning can be differentially modulated by components of the immune system. Interferon-γ (IFNγ) is a pro-inflammatory cytokine whose production is altered in many conditions displaying some degree of cognitive deficits, although its role in cognitive functioning is still unclear. Here we show that the absence of IFNγ selectively enhances cognitive behaviours in tasks in which the hippocampus is impl...
The thymus as a target for mycobacterial infections
Nobrega, Claudia; Cardona, Pere-Joan; Roque, Susana; Pinto do Ó, Perpétua; Appelberg, Rui; Correia-Neves, M.Mycobacterial infections are among the major health threats worldwide. Ability to fight these infections depends on the host's immune response, particularly on macrophages and T lymphocytes produced by the thymus. Using the mouse as a model, and two different routes of infection (aerogenic or intravenous), we show that the thymus is consistently colonized by Mycobacterium tuberculosis, Mycobacterium avium or My...