13 documents found, page 1 of 2
People with primary progressive multiple sclerosis have a lower number of centr...
Gomes, João Manuel Canto; Da Silva-Ferreira, Sara; Silva, Carolina S.; Boleixa, Daniela; Martins da Silva, Ana; González-Suárez, InésThe importance of circulating immune cells to primary progressive multiple sclerosis (PPMS) pathophysiology is still controversial because most immunotherapies were shown to be ineffective in treating people with PPMS (pwPPMS). Yet, although controversial, data exist describing peripheral immune system alterations in pwPPMS. This study aims to investigate which alterations might be present in pwPPMS free of dis...
Impact of inflammation on chronic limb-threatening ischaemia
Ferreira, Joana; Cunha, Pedro; Carneiro, Alexandre; Medeiros, Teresa; Longatto-Filho, Adhemar; Mesquita, Amílcar; Correia-Neves, MargaridaINTRODUCTION: Peripheral arterial disease (PAD) affects more than 202 million people worldwide, 1.3% of which with chronic limb-threatening ischaemia (CLTI). PAD is associated with an elevated mortality and morbidity. However, the evolution from claudication or from asymptomatic PAD to CLTI is not completely understood and cardiovascular risk factors are unable to fully explain it. The aim of this opportunistic...
Iodine supplementation: compliance and association with adverse obstetric and n...
Lopes-Pereira, Maria; Quialheiro, Anna; Costa, Patrício; Roque, Susana; Correia Santos, Nadine; Correia-Neves, Margarida; Goios, Ana; Carvalho, IvoneObjectives: Over 1.9 billion people worldwide are living in areas estimated to be iodine insufficient. Strategies for iodine supplementation include campaigns targeting vulnerable groups, such as women in pre-conception, pregnancy and lactation. Portuguese women of childbearing age and pregnant women were shown to be mildly-to-moderately iodine deficient. As a response, in 2013, the National Health Authority (N...
Manual do projeto OITO: oficinas de inclusão tecnológica online
Quialheiro, Anna; Miranda, André; Garcia Júnior, Miguel; Santos, Nadine Correia; Camargo, Adriana; Correia-Neves, MargaridaO Projeto OITO originou-se pela dificuldade ou falta de acesso dos idosos às plataformas online durante os períodos de confinamento provocados pela pandemia COVID-19. A metodologia do Projeto OITO envolve conteúdos de apoio à inclusão digital no ambiente online, a partir de um dispositivo móvel, especificamente o telemóvel do tipo smartphone ou tablet. A metodologia do OITO é baseada na metodologia da Oficina d...
Impact of iodine supplementation during preconception, pregnancy and lactation ...
Lopes-Pereira, Maria; Roque, Susana; Costa, Patrício; Quialheiro, Anna; Santos, Nadine Correia; Goios, Ana; Vilarinho, Laura; Correia-Neves, MargaridaBackground: Iodine deficiency is the most common cause of preventable brain harm and cognitive impairment in children. Portuguese women of childbearing age, pregnant women and their progeny were shown to have inadequate iodine intake. Consequently, the Portuguese Health Authorities have recommended a daily supplementation with 150-200 µg iodine in preconception, pregnancy, and lactation. The IodineMinho study i...
Evolutionary analysis of Mycobacterium bovis genotypes across Africa suggests c...
Inlamea, Osvaldo Frederico; Soares, Pedro; Ikuta, Cassia Yumi; Heinemann, Marcos Bryan; Achá, Sara Juma; Machado, Adelina; Ferreira Neto, José SoaresMycobacterium bovis is the pathogenic agent responsible for bovine tuberculosis (bTB), a zoonotic disease affecting mostly cattle, but also transmittable to humans and wildlife. Genetic studies on M. bovis allow to detect possible routes of bTB transmission and the identification of genetic reservoirs that may provide an essential framework for public health action. We used a database with 1235 M. bovis genotyp...
A mouse model reproducing the pathophysiology of neonatal group B streptococcal...
Bonifácio Andrade, Elva; Magalhães, Ana; Puga, Ana; Costa, Madalena; Bravo, Joana; Portugal, Camila Cabral; Ribeiro, Adília; Correia-Neves, MargaridaGroup B streptococcal (GBS) meningitis remains a devastating disease. The absence of an animal model reproducing the natural infectious process has limited our understanding of the disease and, consequently, delayed the development of effective treatments. We describe here a mouse model in which bacteria are transmitted to the offspring from vaginally colonised pregnant females, the natural route of infection. ...
Analysis of a Local HIV-1 Epidemic in Portugal Highlights Established Transmiss...
Carvalho, Alexandre; Costa, Patrício Soares; Triunfante, Vera; Branca, Fernando; Rodrigues, Fernando; Santos, Catarina L.; Correia-Neves, MargaridaThe existing data supports Portugal as the Western Europe country with highest HIV-1 subtype diversity. However, detailed phylogenetic studies of Portuguese HIV-1 epidemics are still scarce. Thus, our main goal was to analyze the phylodynamics of a local HIV-1 infection in the Portuguese region of Minho. Molecular epidemiological analysis was applied to data from 289 HIV-1 infected individuals followed in the r...
Artificial thymus: a tissue engineering strategy
Costa-Pinto, A. R.; Serre-Miranda, C.; Rodrigues, Bruno Cerqueira; Martins, Albino; Alves da Silva, Marta L.; Correia-Neves, Margarida; Neves, N. M.The thymus is the central organ responsible for the generation of T lymphocytes (1). Various diseases cause the thymus to produce in- sufficient T cells, which can lead to immune-suppression (2). Since T cells are essential for the protection against pathogens, it is crucial to promote de novo differentiation of T cells on diseased individuals. The available clinical solutions are: 1) one protocol involving the...
Lipocalin 2 modulates the cellular response to amyloid beta
Mesquita, S. D.; Ferreira, A. C.; Falcão, A. M.; Souza, João Carlos Cruz; Oliveira, Tiago Gil; Correia-Neves, Margarida; Sousa, N.; Marques, F.The production, accumulation and aggregation of amyloid beta (Aß) peptides in Alzheimer's disease (AD) are influenced by different modulators. Among these are iron and iron-related proteins, given their ability to modulate the expression of the amyloid precursor protein and to drive Aß aggregation. Herein, we describe that lipocalin 2 (LCN2), a mammalian acute-phase protein involved in iron homeostasis, is high...